Bromosporine
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Bromosporine是bromodomains的广谱抑制剂,作用于BRD2、BRD4和BRD9,IC50值分别为0.41 μM、0.29 μM和0.122 μM[1]。
Bromodomains是一个含110个氨基酸的蛋白结构域,可以识别单乙酰赖氨酸残基,在将染色质修饰酶靶向特异性位点方面起关键作用。据报道,包含BRDs的蛋白参与许多疾病的发展,包括癌症、炎症性疾病和神经系统疾病。
据报道,bromosporine作用于BAZ2A、BRPF3、CECR2、FALZ和TIF-1α,IC50值分别为9.36 μM、48.11 μM、0.017 μM、5.655 μM和12.38 μM[1]。
参考文献:
[1]. University of Oxford. Structural Genomics Consortium Nuffield Dept. of Clinical Medicine. 15th Hellenic Symposium of Medicinal Chemistry Athens, 30, May, 2012.
Physical Appearance | A solid |
Storage | Store at -20°C |
M.Wt | 404.44 |
Cas No. | 1619994-69-2 |
Formula | C17H20N6O4S |
Solubility | ≥40.4 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O |
Chemical Name | ethyl (3-methyl-6-(4-methyl-3-(methylsulfonamido)phenyl)-[1,2,4]triazolo[4,3-b]pyridazin-8-yl)carbamate |
SDF | Download SDF |
Canonical SMILES | CC1=C(NS(C)(=O)=O)C=C(C2=NN3C(C(NC(OCC)=O)=C2)=NN=C3C)C=C1 |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |
描述 | Bromosporine是一种非选择性的bromodomain抑制剂。 | |||||
靶点 | bromodomain | |||||
IC50 |