Brinzolamide
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Brinzolamide(派立明)是碳酸酐酶II(CA II)的有效选择性抑制剂,IC50值为3.19 nM[1]。
Brinzolamide是CA II的最新抑制剂,被成功开发并投入市场,是一种用于治疗青光眼的安全有效的药物。在体外实验中,Brinzolamide对CA-II产生高亲和力和抑制效力,Ki值为0.13 nM,IC50为3.19 nM。与CA-1和CAIV相比,它对CA-II具有更高的亲和力和更大的效力。在氩激光小梁成形术诱导的青紫蓝兔和猕猴高眼压症模型中,Brinzolamide显著降低眼内压(IOP)[1]。
作为CA的抑制剂,brinzolamide也用于评估脑血流储备,它可以保存组织中的CO2,CO2可作用于血管,促进血管舒张。此外,Brinzolamide是用于降低眼内压的一种安全有效的药物[1]。
参考文献:
[1] DeSantis L. Preclinical overview of brinzolamide. Surv Ophthalmol. 2000 Jan;44 Suppl 2:S119-29.
Physical Appearance | A solid |
Storage | Store at -20°C |
M.Wt | 383.51 |
Cas No. | 138890-62-7 |
Formula | C12H21N3O5S3 |
Solubility | insoluble in H2O; ≥15.05 mg/mL in DMSO; ≥8.82 mg/mL in EtOH with gentle warming and ultrasonic |
Chemical Name | (4R)-4-(ethylamino)-2-(3-methoxypropyl)-1,1-dioxo-3,4-dihydrothieno[3,2-e]thiazine-6-sulfonamide |
SDF | Download SDF |
Canonical SMILES | CCNC1CN(S(=O)(=O)C2=C1C=C(S2)S(=O)(=O)N)CCCOC |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |
质量控制和MSDS
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