BRD73954
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
BRD73954是HDAC的强效选择性抑制剂，对HDAC6和HDAC8的IC50值分别为36和120 nM[1]。
组蛋白去乙酰化酶（HADCs）是一系列酶，去除组蛋白ε-N-乙酰赖氨酸上的乙酰基，使组蛋白与DNA更紧密地结合，阻止DNA转录[1]。
BRD73954是HDAC的有效选择性抑制剂，对HDAC6和HDAC8的IC50值分别为36和120 nM。此外，BRD73954抑制HDAC1、HDAC2、HDAC3、HDAC4、HDAC5、HDAC7和HDAC9的活性，IC50值分别为12、9.0、23、> 33、> 33、13和 > 33 μM。在HeLa细胞中，BRD73954显著增加α-微管蛋白的乙酰化，其是HDAC6的底物，但是组蛋白H3的乙酰化状态没有改变，组蛋白H3是HDAC1、2和3的底物[1]。
参考文献：
[1]. Olson DE, Wagner FF, Kaya T, et al. Discovery of the first histone deacetylase 6/8 dual inhibitors. J Med Chem, 2013, 56(11): 4816-4820.
| Physical Appearance | A crystalline solid |
| Storage | Store at -20°C |
| M.Wt | 284.31 |
| Cas No. | 1440209-96-0 |
| Formula | C16H16N2O3 |
| Solubility | ≥46.4 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O |
| Chemical Name | N1-hydroxy-N3-phenethylisophthalamide |
| SDF | Download SDF |
| Canonical SMILES | ONC(C1=CC=CC(C(NCCC2=CC=CC=C2)=O)=C1)=O |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
质量控制和MSDS
- 批次:
化学结构
相关生物数据
