BP 554 maleate
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
BP-554 maleate是一种选择性的5-HT1A受体激动剂[1].
5-HT1A受体是一种G蛋白偶合受体,是内源性神经递质血清素(5-HT)的受体,介导抑制性神经传递.
BP-554 maleate是一种选择性的5-HT1A受体激动剂.相比5-HT1-non-A\5-HT 2\α2肾上腺素能\多巴胺D2和苯并二氮卓受体,BP-554对5-HT1A受体显示出较高的亲和力.在大鼠海马膜中,BP-554抑制毛喉素刺激的腺苷酸环化酶活性[1].
在小鼠中,BP-554抑制脱羧酶抑制后5-羟色氨的积累,并减少脑中5-羟基吲哚乙酸的浓度.另外,BP-554升高血清皮质酮水平并诱导低温症[1].5-HT1(A)受体\5-羟色胺\脑源性神经营养因子(BDNF)受体trkB和BDNF形成一个自/旁分泌环路以调节血清素表型.在大鼠中,BP-554剂量依赖性地增加表达血清素标志物的神经元数量[2].在猴子中,注射BP554到初级视皮层可降低多单元活动(MUA)而不影响血氧水平依赖(BOLD)性和局部场电位(LFP)活性 [3].
参考文献：
[1]. Matsuda T, Seong YH, Aono H, et al. Agonist activity of a novel compound, 1-[3-(3,4-methylenedioxyphenoxy)propyl]-4-phenyl piperazine (BP-554), at central 5-HT1A receptors. Eur J Pharmacol, 1989, 170(1-2): 75-82.
[2]. Galter D, Unsicker K. Sequential activation of the 5-HT1(A) serotonin receptor and TrkB induces the serotonergic neuronal phenotype. Mol Cell Neurosci, 2000, 15(5): 446-455.
[3]. Rauch A, Rainer G, Logothetis NK. The effect of a serotonin-induced dissociation between spiking and perisynaptic activity on BOLD functional MRI. Proc Natl Acad Sci U S A, 2008, 105(18): 6759-6764.
| Physical Appearance | Off-white solid |
| Storage | Store at RT |
| M.Wt | 456.48 |
| Cas No. | 82900-57-0 |
| Formula | C20H24N2O3·C4H4O4 |
| Solubility | <45.65mg/ml in DMSO |
| Chemical Name | 1-(3-(benzo[d][1,3]dioxol-5-yloxy)propyl)-4-phenylpiperazine maleate |
| SDF | Download SDF |
| Canonical SMILES | O=C(O)/C([H])=C([H])\C(O)=O.C1(N2CCN(CC2)CCCOC3=CC4=C(OCO4)C=C3)=CC=CC=C1 |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
化学结构
