BMS 493
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
BMS493是pan-视黄酸受体（pan-RARs）的反相激动剂。该物质可增加核共阻遏物（NCoR）与RAR的相互作用。
视黄酸受体（RAR）是一类核受体，是配体依赖的转录因子，可被9-顺式视黄酸和全反式视黄酸活化。激动配体结合RAR可引起共阻遏物解离和共激活蛋白的募集，从而促进下游靶基因转录为mRNA，最终合成蛋白质。该蛋白可控制多种生理过程，包括细胞生长、分化、存活和死亡。
在细胞培养物中，BMS493预处理MEPM细胞可阻断atRA诱导的细胞凋亡指数。从机理上说，该物质可完全抑制atRA诱导的Sub-G1分数、DNA断裂和caspase-3活化[1]。
在体内，使用BMS493抑制RAR信号可诱导程度非常高的先天性膈疝，这与取决于药物递送时间的显著的左右片面性有关[2]。
参考文献：
1. Yu Z, Han J, Lin J, et al. Apoptosis induced by atRA in MEPM cells is mediated through activation of caspase and RAR. Toxicological sciences : an official journal of the Society of Toxicology. 2006;89(2):504-509.
2. Clugston RD, Zhang W, Alvarez S, et al. Understanding abnormal retinoid signaling as a causative mechanism in congenital diaphragmatic hernia. American journal of respiratory cell and molecular biology. 2010;42(3):276-285.
| Physical Appearance | A crystalline solid |
| Storage | Store at -20°C |
| M.Wt | 404.5 |
| Cas No. | 215030-90-3 |
| Formula | C29H24O2 |
| Solubility | Soluble in DMSO |
| Chemical Name | (E)-4-(2-(5,5-dimethyl-8-(phenylethynyl)-5,6-dihydronaphthalen-2-yl)vinyl)benzoic acid |
| SDF | Download SDF |
| Canonical SMILES | OC(C1=CC=C(C=C1)/C=C/C2=CC=C3C(C)(C)CC=C(C#CC4=CC=CC=C4)C3=C2)=O |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
化学结构
