BIM 23056
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
IC50:SSTR3的IC50为0.02 nM.
生长抑素(SRIF)是一种环状十四肽,最初是从哺乳动物下丘脑分离得到的,是垂体前叶生长激素分泌的生理调节剂.BIM 23056是SRIF SSTR3的新型拮抗剂,是一种线性肽.
体外实验:BIM 23056以亚纳摩尔亲和力与SSTR3结合.BIM 23056对SSTR3具有显著的选择性,浓度高达1 μM的BIM 23056与SSTR1或SSTR2没有显著的相互作用.BIM 23056对SSTR3产生30,000倍的选择性,在未来研究中可以作为SSTR3的选择性配体[1].此外,研究发现,BIM 23056可以作为人重组sst5受体的有效的和可耐受的拮抗剂.这种拮抗作用具有一定的特异性,BIM 23056不抑制UTP诱导的[Ca2+]或Ins(1,4,5)P3的增加[2].
在体实验:没有相关的在体动物实验数据.
临床试验:截至目前,BIM 23056还处于临床前开发阶段.
参考文献：
[1] Raynor K, Murphy WA, Coy DH, Taylor JE, Moreau JP, Yasuda K, Bell GI, Reisine T. Cloned somatostatin receptors: identification of subtype-selective peptides and demonstration of high affinity binding of linear peptides. Mol Pharmacol. 1993 Jun;43(6):838-44.
[2] Wilkinson GF, Thurlow RJ, Sellers LA, Coote JE, Feniuk W, Humphrey PP. Potent antagonism by BIM-23056 at the human recombinant somatostatin sst5 receptor. Br J Pharmacol. 1996 Jun;118(3):445-7.
| Physical Appearance | White lyophilised solid |
| Storage | Desiccate at -20°C |
| M.Wt | 1232.49 |
| Cas No. | 150155-61-6 |
| Formula | C71H81N11O9 |
| Solubility | Soluble to 1 mg/ml in 20% acetonitrile / H2O |
| SDF | Download SDF |
| Canonical SMILES | CC([C@@](/N=C(O)/[C@](/N=C(O)/[C@@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/[C@@](N)([H])CC1=CC=CC=C1)([H])CC2=CC=CC=C2)([H])CC3=CC=C(O)C=C3)([H])CC4=CNC5=CC=CC=C45)([H])CCCCN)([H])/C(O)=N/[C@@](/C(O)=N/[C@](C(O)=N)([H])CC6=CC7=CC=CC=C7C=C6)([H])CC8=CC=CC=C8)C |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
化学结构
