BIM 23042
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Ki:在huNMBR细胞中,神经介素B诱导端点的Ki值为49 ± 14 nM.
神经介素B属于哺乳动物的蛙皮素样肽家族,与对应的两栖类动物ranatensin具有一定的氨基酸同源性,在中枢和外周组织中诱导多种生物学应答.BIM 23042(D-Nal-Cys-Tyr- D-Trp-Lys-Val-Cys-Nal-NH2)是一种选择性神经介素B拮抗剂.
体外实验:与BB2受体相比,BIM 23042对BB1受体具有100倍的更大亲和力.BIM 23042废除1 nM神经介素B的亚最大动员,随后更高浓度(1 μM)的神经介素B恢复这种作用.在huNMBR细胞中,BIM 23042竞争性抑制神经介素B诱导的端点,Ki值为49 ± 14 nM[1].
临床试验:截至目前,BIM 23042还处于临床前开发阶段.
参考文献:
[1] Ryan RR, Taylor JE, Daniel JL, Cowan A. Pharmacological profiles of two bombesin analogues in cells transfected with human neuromedin B receptors. Eur J Pharmacol. 1996 Jun 13;306(1-3):307-14.
Physical Appearance | White lyophilised solid |
Storage | Desiccate at -20°C |
M.Wt | 1192.47 |
Cas No. | 111857-96-6 |
Formula | C63H73N11O9S2 |
Solubility | ≥43.8 mg/mL in DMSO; ≥42.7 mg/mL in EtOH; ≥8.04 mg/mL in H2O with ultrasonic |
Chemical Name | (4R,7S,10S,13R,16S,19R)-13-((1H-indol-3-yl)methyl)-N-((S)-1-amino-3-(naphthalen-2-yl)-1-oxopropan-2-yl)-19-((R)-2-amino-3-(naphthalen-2-yl)propanamido)-10-(4-aminobutyl)-16-(4-hydroxybenzyl)-7-isopropyl-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaa |
SDF | Download SDF |
Canonical SMILES | O=C(N[C@H](CC1=CNC2=CC=CC=C21)C(N[C@@H](CCCCN)C(N[C@H]3C(C)C)=O)=O)[C@@H](NC([C@H](CSSC[C@@H](C(N[C@@H](CC4=CC(C=CC=C5)=C5C=C4)C(N)=O)=O)NC3=O)NC([C@@H](CC6=CC7=C(C=CC=C7)C=C6)N)=O)=O)CC8=CC=C(O)C=C8 |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |
质量控制和MSDS
- 批次: