Bikinin
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Bikinin是油菜素类固醇(BR)信号的强激活剂[1],也是糖原合酶激酶3蛋白(GSK3)的抑制剂[2].
BR是一类多羟基化的类固醇激素,牵涉多个发育过程,包括茎伸长\叶片扩展\维管发育\种子萌发和对生物及非生物胁迫的抗逆性.BR生物合成或感知的遗传缺陷可导致植株矮小\叶片墨绿和卷曲\种子发芽率和产率下降及在黑暗中去黄化.[1]
Bikinin是第一个调控BRI1受体下游BR信号级联的非类固醇分子.Bikinin可直接靶向BIN2,活化BR依赖的基因表达.Bikinin的应用可部分地使bri1功能缺陷突变株和bin2功能获得突变株的表型回复为野生型.Bikinin可完全挽救bin2功能获得突变株的下胚轴和叶柄矮小.Bikinin可完全复原这一突变株的BR相关表型,而对生长素相关表型没有效果.[1]
Bikinin处理也可引发Nicotiana benthamiana叶盘管状元件分化,这一叶盘培养体系可能也适用于不同的植物种.[2]
参考文献:
[1]. De Rybel B, Audenaert D, Vert G et al. Chemical inhibition of a subset of Arabidopsis thaliana GSK3-like kinases activates brassinosteroid signaling. Chem Biol. 2009 Jun 26;16(6):594-604.
[2]. Kondo Y, Fujita T, Sugiyama M, Fukuda H. A Novel System for Xylem Cell Differentiation in Arabidopsis thaliana. Mol Plant. 2014 Dec 13. pii: S1674-2052(14)00026-4.
Physical Appearance | A solid |
Storage | Store at -20°C |
M.Wt | 273.08 |
Cas No. | 188011-69-0 |
Formula | C9H9BrN2O3 |
Solubility | insoluble in H2O; ≥13.65 mg/mL in DMSO; ≥2.4 mg/mL in EtOH |
Chemical Name | 4-((5-bromopyridin-2-yl)amino)-4-oxobutanoic acid |
SDF | Download SDF |
Canonical SMILES | BrC1=CN=C(NC(CCC(O)=O)=O)C=C1 |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |
质量控制和MSDS
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