BIBX 1382
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
BIBX 1382是一种强效的、选择性的表皮生长因子受体(EGFR)酪氨酸激酶抑制剂,IC50值为3 nM。[1]
BIBX 1382是一种用于癌症治疗的EGFR激酶抑制剂。使用在Sf9昆虫细胞中克隆和表达的HER2、VEGFR2、HGFR、IGF1R、B InsRK和c-src的胞质酪氨酸激酶结构域进行酪氨酸激酶活性测定,BIBX1382选择性地强效抑制EGFR激酶活性,IC50值为3 nM。使用EGFR高表达的A431细胞(vuval鳞状细胞癌)进行EGFR和pEGFR ELISA测定,BIBX1382抑制EGFR磷酸化,EC50为141 nM。[1] 在A431、FaDu(下咽鳞状细胞癌)和HN5(头颈部鳞状细胞癌)异种移植裸鼠模型中,10 mg/kg 日剂量的BIBX1382口服给药2周后显示强烈的剂量依赖性抗肿瘤活性。此外,50 mg/kg 日剂量的BIBX1382长期口服给药170天后,A431异种移植小鼠模型中肿瘤消退。[1]
参考文献:
1. F. F. Solca, A. Baum, E. Langkopf, G. Dahmann, K. H. Heider, F. Himmelsbach and J. C. van Meel, J Pharmacol Exp Ther 2004, 311, 502-509.
Storage | Store at -20°C |
M.Wt | 387.84 |
Cas No. | 196612-93-8 |
Formula | C18H19ClFN7 |
Synonyms | Falnidamol;BIBX-1382;BIBX1382 |
Solubility | Soluble in DMSO |
Chemical Name | N8-(3-chloro-4-fluorophenyl)-N2-(1-methylpiperidin-4-yl)pyrimido[5,4-d]pyrimidine-2,8-diamine |
SDF | Download SDF |
Canonical SMILES | CN1CCC(NC2=NC=C3C(C(NC4=CC(Cl)=C(F)C=C4)=NC=N3)=N2)CC1 |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |