Beta-Sheet Breaker Peptide iAβ5
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
β-Sheet Breaker Peptide iAβ5的化学式为C33H43N5O8，多肽序列为H-Leu-Pro-Phe-Phe-Asp-OH。在大鼠模型中，它能抑制淀粉样蛋白的生成。研究表明，在淀粉样变的大鼠模型中，β-Sheet Breaker Peptide显著减少体内β淀粉样蛋白的沉积，完全阻止淀粉样蛋白原纤维的形成。目前的证据表明，β-淀粉样蛋白沉积或Aβ中间体在阿尔茨海默氏病（AD）患者的发病机制中发挥重要作用。β-Sheet Breaker Peptide可以抑制脑中β淀粉样蛋白的沉积，是治疗阿尔茨海默氏病的重要靶标。
参考文献：
1. C. Soto, E.M. Sigurdsson, L. Morelli, R.A. Kumar, E.M. Castano, and B. Frangione, Nat. Med., 4, 822 (1998) (Original; Pharmacol.)
2. MA Chacon, MI Barria, C Soto and NC Inestrosa. Beta-sheet breaker peptide prevents Abeta-induced spatial memory impairments with partial reduction of amyloid deposits.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 637.73 |
| Cas No. | 182912-74-9 |
| Formula | C33H43N5O8 |
| Synonyms | H2N-Leu-Pro-Phe-Phe-Asp-OH |
| Solubility | ≥63.7 mg/mL in DMSO; ≥16.33 mg/mL in EtOH; ≥6.9 mg/mL in H2O with ultrasonic |
| SDF | Download SDF |
| Canonical SMILES | N[C@@H](CC(C)C)C(N1[C@@H](CCC1)C(N[C@@H](CC2=CC=CC=C2)C(N[C@@H](CC3=CC=CC=C3)C(N[C@@H](CC(O)=O)C(O)=O)=O)=O)=O)=O |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
质量控制和MSDS
- 批次:
化学结构
