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Beauvericin

现货
Catalog No.
B6113
抗菌和抗真菌活性
组合的产品项目
规格价格库存 数量
5mg
¥ 1,080.00
Ship with 10-15 days
10mg
¥ 1,920.00
Ship with 10-15 days

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Background

IC50: 1.9 μM for antiviral activity; 1.7 μM for antimalarial activity

Beauvericin is a mycotoxin produced by various fungi including Fusarium spp. and Beaveria bassiana. As a cyclic hexadepsipeptide belonging to the enniatin antibiotic family, beauvericin contains three D-hydroxyisovaleryl and three N-methylphenylalanyl residues. Beauvericin was one of the active constituents of B. bassiana and was confirmed to have antibacterial and antifungal activities.

In vitro: Beauvericin has a strong antibacterial activity against human, animal and plant pathogenic bacteria, without selectivity between Gram-positive and Gram-negative bacteria. Unlike other antibiotics blocking the peptidoglycan biosynthesis, beauvericin does not target on the bacterial cell wall. Although it has broad-spectrum antibacterial activities, the antifungal activity of beauvericin is rarely reported as a single agent. Thus, the target of beauvericin is regarded to be different between bacteria and fungi and the activities of beauvericin need to be investigated against drug resistant bacteria [1].

In vivo: Previous study reported the the antifungal activity of beauvericin combined with miconazole or ketoconazole. Beauvericin at 0.5 mg/kg combined with ketoconazole at 0.5 mg/kg showed significant antifungal activity against Candida parapsilosis, which could cause high mortality rates quickly, particularly in neonates. In contrast, both beauvericin and ketoconazole alone have little to no inhibitory effect on C. parapsilosis [1].

Clinical trial: N/A

Reference:
[1] Wang Q, Xu L.  Beauvericin, a bioactive compound produced by fungi: a short review. Molecules. 2012 Feb 24;17(3):2367-77.

Chemical Properties

Physical AppearanceA crystalline solid
StorageStore at -20°C
M.Wt783.95
Cas No.26048-05-5
FormulaC45H57N3O9
SolubilitySoluble in DMSO
Chemical Name(3S,9S,15S)-3,9,15-tribenzyl-6,12,18-triisopropyl-4,10,16-trimethyl-1,7,13-trioxa-4,10,16-triazacyclooctadecane-2,5,8,11,14,17-hexaone
SDFDownload SDF
Canonical SMILESCC(C(OC([C@](N(C(C(O1)([H])C(C)C)=O)C)([H])CC2=CC=CC=C2)=O)([H])C(N([C@@](C(OC(C(N([C@@](C1=O)([H])CC3=CC=CC=C3)C)=O)([H])C(C)C)=O)([H])CC4=CC=CC=C4)C)=O)C
运输条件试用装:蓝冰运输。 其他可选规格:常温运输或根据您的要求用蓝冰运输。
一般建议为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。

质量控制

质量控制和MSDS

批次:

化学结构

Beauvericin