BAY 57-1293
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
BAY 57-1293是一种有效且安全的HSV解旋酶-引物酶抑制剂，IC50值为12 nM[1]。
BAY 57-1293可抑制解旋酶-引物酶并能影响病毒DNA合成，因而具有抗疱疹活性。在体外病毒复制试验中，BAY 57-1293对HSV-1 F、HSV-2 G和阿昔洛韦耐受的HSV-1 F突变株有抑制能力，IC50值为20 nM。在噬菌斑减少试验和传统的细胞致病性试验中，BAY 57-1293的IC50值分别为0.01-0.02 μM和0.01-0.03 μM。除此之外，BAY 57-1293对所有HSV-1和HSV-2的临床分离株均均有活性，IC50值为10 nM–30 nM。另外，BAY 57-1293在体内有活性。口服BAY 57-1293在感染疱疹的小鼠模型中比伐昔洛韦强效10倍。在大鼠致死挑战模型中，BAY 57-1293具有突出的抗病毒活性而无毒性效应。[1,2]
参考文献：
[1] Kleymann G, Fischer R, Betz U A K, et al. New helicase-primase inhibitors as drug candidates for the treatment of herpes simplex disease. Nature medicine, 2002, 8(4): 392-398.
[2] Betz U A K, Fischer R, Kleymann G, et al. Potent in vivo antiviral activity of the herpes simplex virus primase-helicase inhibitor BAY 57-1293. Antimicrobial agents and chemotherapy, 2002, 46(6): 1766-1772.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 402.49 |
| Cas No. | 348086-71-5 |
| Formula | C18H18N4O3S2 |
| Solubility | insoluble in H2O; insoluble in EtOH; ≥13.9 mg/mL in DMSO |
| Chemical Name | N-methyl-N-(4-methyl-5-sulfamoyl-1,3-thiazol-2-yl)-2-(4-pyridin-2-ylphenyl)acetamide |
| SDF | Download SDF |
| Canonical SMILES | CC1=C(SC(=N1)N(C)C(=O)CC2=CC=C(C=C2)C3=CC=CC=N3)S(=O)(=O)N |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
质量控制和MSDS
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化学结构
