Barnidipine (hydrochloride)
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Barnidipine is a calcium-channel blocker.
A calcium channel, an ion channel which displays selective permeability to calcium ions, is sometimes synonymous as voltage-dependent calcium channel, although there are also ligand-gated calcium channels.
In vitro: The effects of barnidipine on L-type Ca(2+) current (I(Ca(L))) were investigated in rat ventricular cardiomyocytes. It was found that barnidipine reduced I(Ca(L)) in a concentration and voltage dependent manne. Barnidipine induced a leftward shift of the steady-state inactivation curve of I(Ca(L)) [1].
In vivo: A previous study was conducted to investigate the influence of barnidipine treatment on early stage hypertension by determining the mesenteric and renal arteries as well as the kidney in L-NAME-induced hypertensive rats. Barnidipine was applied to rats after 2 weeks of L-NAME administration, and continued for the next 3 weeks concomitantly with L-NAME. Histopathological studies verified structural alterations in the arteries and the kidney. Moreover, a decrease in endothelial nitric oxide synthase expression was observed both in the arteries and kidney of hypertensive rats with barnidipine treatment [2].
Clinical trial: In patients with hypertension and type 2 diabetes mellitus, it was found that barnidipine treatment led to a significant reduction in blood pressure. Data recorded with ABPM also showed a similar trend. Barnidipine + losartan could reduce the levels of Hs-CRP, TNF-α, sVCAM-1, sICAM-1, and isoprostanes [3].
References:
[1] Wegener JW, Meyrer H, Rupp J, Nawrath H. Barnidipine block of L-type Ca(2+) channel currents in rat ventricular cardiomyocytes. Br J Pharmacol. 2000 Aug;130(8):2015-23.
[2] Alp Yildirim FI, Eker Kizilay D, Ergin B, Balci Ekmeki, Topal G, Kucur M, Demirci Tansel C, Uyde Doan BS. Barnidipine ameliorates the vascular and renal injury in L-NAME-induced hypertensive rats. Eur J Pharmacol. 2015 Oct 5;764:433-42.
[3] Derosa G, Mugellini A, Pesce RM, D'Angelo A, Maffioli P. Barnidipine compared to lercanidipine in addition to losartan on endothelial damage and oxidative stress parameters in patients with hypertension and type 2 diabetes mellitus. BMC Cardiovasc Disord. 2016 Apr 12;16:66.
Storage | Store at 4°C |
M.Wt | 528 |
Cas No. | 104757-53-1 |
Formula | C27H29N3O6·HCl |
Synonyms | YM 09730-5 |
Solubility | insoluble in H2O; insoluble in EtOH; ≥16.3 mg/mL in DMSO with gentle warming |
Chemical Name | (4S)-3,5-pyridinedicarboxylic acid, 3-methyl 5-[(3S)-1-(phenylmethyl)-3-pyrrolidinyl] ester, monohydrochloride |
SDF | Download SDF |
Canonical SMILES | CC1=C(C(O[C@@H]2CN(CC3=CC=CC=C3)CC2)=O)[C@H](C(C(OC)=O)=C(C)N1)C4=CC([N+]([O-])=O)=CC=C4.Cl |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |
质量控制和MSDS
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