Aztreonam
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Physical Appearance | A solid |
Storage | Store at -20°C |
M.Wt | 435.43 |
Cas No. | 78110-38-0 |
Formula | C13H17N5O8S2 |
Solubility | insoluble in EtOH; ≥10.24 mg/mL in H2O with ultrasonic; ≥18.9 mg/mL in DMSO |
Chemical Name | 2-[(Z)-[1-(2-amino-1,3-thiazol-4-yl)-2-[[(2S,3S)-2-methyl-4-oxo-1-sulfoazetidin-3-yl]amino]-2-oxoethylidene]amino]oxy-2-methylpropanoic acid |
SDF | Download SDF |
Canonical SMILES | CC1C(C(=O)N1S(=O)(=O)O)NC(=O)C(=NOC(C)(C)C(=O)O)C2=CSC(=N2)N |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |
细胞实验 [1]: | |
细胞系 |
人骨髓细胞 |
溶解方法 |
在DMSO中的溶解度≥18.9mg/mL 。为了获得更高的浓度,可以将离心管在37℃加热10分钟和/或在超声波浴中震荡一段时间。原液可以在-20℃以下储存几个月。 |
反应条件 |
230.0mg/l, 5.0mg/l |
应用 |
Aztreonam在峰值和谷值血清浓度下均能显著抑制人类菌落形成单位-红细胞(CFU-E)单位红细胞(BFU-E)和菌落形成单位 - 粒细胞巨噬细胞(CFU-GM)。 |
动物实验 [2]: | |
动物模型 |
雄性食蟹猴 |
剂量 |
40,150 and 300 mg/kg(i.v.), 一天一次,持续4周 |
应用 |
用Aztreonam以40至300 mg / kg的剂量治疗食蟹猴4周,导致肝微粒体P450含量显着降低。另一方面,用aztreonam治疗后,肝细胞色素b5含量和NADPH-细胞色素c(P450)还原酶活性未见明显变化。用aztreonam治疗食蟹猴后,肝微粒体中的睾丸激素6β-羟化酶的活性降低,但2β-和16α-羟化酶的活性没有降低。Aztreonam可降低食蟹猴肝脏微粒体中的P450 CMLc。 |
注意事项 |
请测试所有化合物在室内的溶解度,实际溶解度和理论值可能略有不同,这是由实验系统的误差引起的,属于正常现象。 |
References: [1]. Charak BS, Louie R, Malloy B, Twomey P, Mazumder A. The effect of amphotericin B, aztreonam, imipenem and cephalosporins on the bone marrow progenitor cell activity. J Antimicrob Chemother. 1991 Jan;27(1):95-104. PubMed PMID: 2050599. [2]. Ohmori S, Horie T, Hayashi S, Kitada M. Aztreonam decreases hepatic microsomal cytochrome P450 in cynomolgus monkeys. Pharmacology. 1994 Mar;48(3):137-42. PubMed PMID: 8153141. |
质量控制和MSDS
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