AZD2932
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
AZD2932是多蛋白酪氨酸激酶的强效抑制剂,对VEGFR-2\ PDGFRβ\ Flt-3和c-Kit 的IC50分别为8 nM\4 nM\7 nM和9 nM[1].
VEGFR是血管内皮生长因子的受体,属于受体酪氨酸激酶,介导多种细胞功能,包括内皮细胞增殖\迁移\存活\管状形态发生和出芽.PDGFR是血小板衍生生长因子受体,具有细胞内酪氨酸激酶活性,参与胚胎发育\血管生成\增殖和分化等.
AZD2932可以强效的平衡抑制PDGFR\VEGFR-2\Flt-3和c-Kit,IC50为0.009.它具有较好的游离分数,人血清中为3.3％,狗血清中为7.0％,对hERG没有活性[1].
在C6肿瘤雌性裸鼠中,3–50 mg/kg的AZD2932给药治疗每日两次,间隔10小时,抑制60-80％的p-VEGFR-2和p-PDGFRb,抑制比例为1:1[1].
参考文献：
1. Plé PA, Jung F, Ashton S, Hennequin L et al. Discovery of AZD2932, a new Quinazoline Ether Inhibitor with high affinity for VEGFR-2 and PDGFR tyrosine kinases. Bioorg Med Chem Lett. 2012 Jan 1;22(1):262-6.
| Physical Appearance | A crystalline solid |
| Storage | Store at -20°C |
| M.Wt | 447.49 |
| Cas No. | 883986-34-3 |
| Formula | C24H25N5O4 |
| Solubility | Soluble in DMSO |
| Chemical Name | (Z)-2-(4-((6,7-dimethoxyquinazolin-4-yl)oxy)phenyl)-N-(1-isopropyl-1H-pyrazol-4-yl)acetimidic acid |
| SDF | Download SDF |
| Canonical SMILES | CC(N1C=C(/N=C(O)/CC2=CC=C(OC3=NC=NC4=CC(OC)=C(OC)C=C43)C=C2)C=N1)C |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
化学结构
