AZ 960
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
AZ960是新型的JAKs（janus相关激酶）抑制剂，对JAK2有较强的抑制作用，Ki? 值为0.45 nmol/L。对其它JAKs家族成员，例如 JAK1、JAK3和TYK2以及其它激酶，包括TrkA、Aurora A和FAK的抑制作用较小，IC50大约为0.1 μmol/L。最近的研究表明AZ960对成人T细胞白血病（ATL），CD4+ T淋巴细胞侵略性恶性肿瘤具有一定的抗癌活性，主要是通过诱导人类T细胞嗜淋巴细胞病毒1型（HTLV-1）感染的T细胞的生长停滞和细胞凋亡发挥作用。
参考文献：
Yang J, Ikezoe T, Nishioka C, Furihata M, Yokoyama A. AZ960, a novel Jak2 inhibitor, induces growth arrest and apoptosis in adult T-cell leukemia cells. Mol Cancer Ther. 2010;9(12):3386-3395.
| Physical Appearance | A crystalline solid |
| Storage | Store at -20°C |
| M.Wt | 354.36 |
| Cas No. | 905586-69-8 |
| Formula | C18H16F2N6 |
| Synonyms | AZ-960,AZ960 |
| Solubility | Soluble in DMSO |
| Chemical Name | 5-fluoro-2-[[(1S)-1-(4-fluorophenyl)ethyl]amino]-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyridine-3-carbonitrile |
| SDF | Download SDF |
| Canonical SMILES | CC1=CC(=NN1)NC2=C(C=C(C(=N2)NC(C)C3=CC=C(C=C3)F)C#N)F |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
| 描述 | AZ960是一种有效的、选择性的和ATP竞争性的JAK2抑制剂，Ki值为0.45 nM。 | |||||
| 靶点 | JAK2 | |||||
| IC50 | 0.45 nM (Ki) | |||||
化学结构
