Atazanavir
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Atazanavir是一种新型有效的氮杂肽类蛋白酶抑制剂，特异性地抑制人类免疫缺陷病毒1型（HIV-1）蛋白酶，抑制常数Ki值为66 nmol/L，也抑制HIV-1病毒的复制，EC50范围介于2.6-5.3 nmol/L之间。在感染HIV-1的细胞中，atazanavir与HIV-1蛋白酶结合，防止gag和gag-pol多聚蛋白的裂解，从而导致不成熟病毒颗粒的形成。与其它蛋白酶抑制剂相比，包括indinavir、nelfinavir、ritonavir、saquinavir和amprenavir，atazanavir具有不同的C-2对称化学结构，且对各种HIV毒株具有更高的抗逆转录病毒效力。
参考文献：
Fuster D, Clotet B. Review of atazanavir: a novel HIV protease inhibitor. Expert Opin Pharmacother. 2005 Aug;6(9):1565-72.
Croom KF, Dhillon S, Keam SJ. Atazanavir: a review of its use in the management of HIV-1 infection. Drugs. 2009 May 29;69(8):1107-40. doi: 10.2165/00003495-200969080-00009.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 704.9 |
| Cas No. | 198904-31-3 |
| Formula | C38H52N6O7 |
| Solubility | ≥28.6 mg/mL in DMSO; insoluble in H2O; ≥9.9 mg/mL in EtOH with ultrasonic |
| Chemical Name | methyl N-[(2S)-1-[2-[(2S,3S)-2-hydroxy-3-[[(2S)-2-(methoxycarbonylamino)-3,3-dimethylbutanoyl]amino]-4-phenylbutyl]-2-[(4-pyridin-2-ylphenyl)methyl]hydrazinyl]-3,3-dimethyl-1-oxobutan-2-yl]carbamate |
| SDF | Download SDF |
| Canonical SMILES | CC(C)(C)C(C(=O)NC(CC1=CC=CC=C1)C(CN(CC2=CC=C(C=C2)C3=CC=CC=N3)NC(=O)C(C(C)(C)C)NC(=O)OC)O)NC(=O)OC |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
| Description | Atazanavir is an inhibitor of HIV protease with Ki of 2.66 nM. | |||||
| Targets | HIV | |||||
| IC50 | 2.6~5.3 nM | |||||
质量控制和MSDS
- 批次:
化学结构
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