Atazanavir sulfate (BMS-232632-05)
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Atazanavir sulfate (BMS-232632-05)是Atazanavir的硫酸酯盐形式,是一个有效的蛋白酶抑制剂(IP),可治疗人类免疫缺陷病毒(HIV-1)感染,在感染的细胞内通过对病毒gag和gag pol多蛋白的病毒特异性过程的选择性抑制,防止成熟的HIV病毒粒形成。虽然Atazanavir具有很强的抗HIV-1活性(MIC50值2 - 5 nM),然而它对HIV-2分离物的抗性较低。Atazanavir是由肝脏细胞色素P450(CYP)系统产生的两个主要不活跃的代谢分子代谢的,也是CYP3A4同工酶和p-糖蛋白ATP依赖的外排泵的一个抑制剂。
参考文献:
Robin Wood. Atazanavir: its role in HIV treatment. Expert Rev Snti Infect Ther 2008; 6(6): 785-796.
Storage | Store at -20°C |
M.Wt | 802.9 |
Cas No. | 229975-97-7 |
Formula | C38H52N6O7·H2SO4 |
Synonyms | Atazanavir Bisulfate SaltSee A790051,BMS232632-05 |
Solubility | ≥28.7 mg/mL in DMSO with gentle warming; insoluble in H2O; ≥4.05 mg/mL in EtOH with gentle warming and ultrasonic |
Chemical Name | methyl N-[(2S)-1-[2-[(2S,3S)-2-hydroxy-3-[[(2S)-2-(methoxycarbonylamino)-3,3-dimethylbutanoyl]amino]-4-phenylbutyl]-2-[(4-pyridin-2-ylphenyl)methyl]hydrazinyl]-3,3-dimethyl-1-oxobutan-2-yl]carbamate;sulfuric acid |
SDF | Download SDF |
Canonical SMILES | CC(C)(C)C(C(=O)NC(CC1=CC=CC=C1)C(CN(CC2=CC=C(C=C2)C3=CC=CC=N3)NC(=O)C(C(C)(C)C)NC(=O)OC)O)NC(=O)OC.OS(=O)(=O)O |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |
质量控制和MSDS
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