AR-C 66096 tetrasodium salt
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
血小板P2T受体在血小板聚集中发挥重要作用,其拮抗剂有显著治疗潜力,可以作为抗血栓剂. AR-C 66096是一种作用于人血小板P2T嘌呤受体的新型有效的选择性拮抗剂.
体外实验:在人洗涤血小板悬浮液中,1-100 nM 的AR-C 66096以浓度依赖性方式引起 ADP诱导血小板凝集的浓度效应曲线(E/[A])右移.孵育时间从2分钟增加到15分钟以及浓度为300 μM的P1-嘌呤受体拮抗剂8磺基茶碱的阻断不影响AR-C 66096的抗聚集效力[1].
在体实验:在制备的离体兔耳动脉中,AR-C 66096可以作为弱的完全P2X嘌呤受体激动剂,pA50为3.68.在离体豚鼠主动脉中,可以作为P2Y嘌呤受体的弱的竞争性拮抗剂,pKB为4.71,表明其对Pzr亚型的选择性至少为9000倍.在后者的制备物中,大于10 μM浓度的 AR-C 66096引起非特异性松弛[1].
临床试验:截至目前,AR-C 66096尚处于临床前开发阶段.
参考文献：
[1] Humphries, R. G.; Tomlinson, W.; Ingall, A. H.; Cage, P. A.; Leff, P. FPL 66096: A Novel, Highly Potent and Selective Antagonist at Human Platelet P2T-purinoceptors. Br. J. Pharmacol. 1994, 113, 1057-1063.
| Physical Appearance | Colourless liquid |
| Storage | Store at -20°C |
| M.Wt | 703.26 |
| Cas No. | 145782-74-7 |
| Formula | C14H18F2N5Na4O12P3S |
| Solubility | <10mM in H2O |
| SDF | Download SDF |
| Canonical SMILES | CCCSC1=NC(N)=C(N=CN2[C@@]3([H])[C@](O)([H])[C@@](O)([H])[C@@](O3)([H])COP([O-])(OP(C(F)(P([O-])([O-])=O)F)([O-])=O)=O)C2=N1.[Na+].[Na+].[Na+].[Na+] |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
化学结构
