切换导航

Anidulafungin

现货
Catalog No.
B1224
抗真菌药
组合的产品项目
规格价格库存 数量
10mM (in 1mL DMSO)
¥ 950.00
现货
100mg
¥ 2,380.00
现货
250mg
¥ 4,850.00
现货

电话: 021-55669583

邮箱: sales@apexbio.cn

全球经销商

Background

Anidulafungin (LY-303366)is a synthetic derivative of echinocandin B, used as a drug of antifungal [1].

Anidulafungin has been reported to inhibit systemic isolates of Candida species with the MIC90 values of 0.08μg/ml, 0.32μg/ml, 0.32μg/ml and 5.12μg/ml for C.albicans (n=99), C.glabrata(n=18), C.tropicalis(n=10), and C.parapsilosis (n=10), respectively. In addition, Anidulafungin has been found to be active against Aspergillus species(n=20) with the MIC90 values of ~0.02μg/ml. Apart from these, Anidulafungin has been revealed to inactively restrain with the MIC90 values of >10.24μg/ml and 16μg/ml, for C.neoformans and B.dermatitidis, respectively [1].

References:
[1] Zhanel GG1, Karlowsky JA, Harding GA, Balko TV, Zelenitsky SA, Friesen M, Kabani A, Turik M, Hoban DJ. In vitro activity of a new semisynthetic echinocandin, LY-303366, against systemic isolates of Candida species, Cryptococcus neoformans, Blastomyces dermatitidis, and Aspergillus species. Antimicrob Agents Chemother. 1997 Apr;41(4):863-5.

文献引用

1. Hoyer AR, Johnson CJ, et al. "Echinocandin Treatment of Candida albicans Biofilms Enhances Neutrophil Extracellular Trap Formation." Antimicrob Agents Chemother. 2018 Aug 27;62(9). pii: e00797-18. PMID:29987146

Chemical Properties

Physical AppearanceA solid
StorageStore at -20°C
M.Wt1140.24
Cas No.166663-25-8
FormulaC58H73N7O17
SolubilitySoluble in DMSO
SDFDownload SDF
Canonical SMILESO[C@H]1[C@H](C)CN(C([C@H]([C@H](C)O)NC([C@H]([C@@H]([C@@H](C(C=C2)=CC=C2O)O)O)NC([C@H](C3)N(C([C@H]([C@H](C)O)NC4=O)=O)C[C@@H]3O)=O)=O)=O)[C@@H]1C(N[C@H]([C@@H](C[C@@H]4NC(C5=CC=C(C6=CC=C(C(C=C7)=CC=C7OCCCCC)C=C6)C=C5)=O)O)O)=O
运输条件试用装:蓝冰运输。 其他可选规格:常温运输或根据您的要求用蓝冰运输。
一般建议为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。

试验操作

抗真菌试验 [1]:

真菌

曲霉菌

制备方法

在DMSO中的溶解度大于10 mM。若配制更高浓度的溶液,一般步骤如下:请将试管置于37 °C加热10分钟和/或将其置于超声波浴中震荡一段时间。原液于-20 °C可放置数月。

反应条件

48小时

实验结果

Anidulafungin有效抑制曲霉菌,其MEC90值为0.02 mg/mL。Anidulafungin对烟曲霉、黄曲霉、黑曲霉、灰绿曲霉以及杂色曲霉的MIC和MEC范围分别为0.00125 ~ 0.005 μg/mL和0.005 ~ 10.24 μg/mL。

动物实验 [2]:

动物模型

感染黄曲霉FMR 9965、FMR 8756、FMR 9960、FMR 10084或FMR 9966的小鼠

给药剂量

1、5或10 mg/kg;腹腔注射;每天1次,持续7天

实验结果

在感染黄曲霉FMR 9965、FMR 8756、FMR 9960、FMR 10084或FMR 9966的小鼠中,5 mg/kg和10 mg/kg Anidulafungin显著延长小鼠存活。5 mg/kg和10 mg/kg剂量组之间无显著差异。此外,在脾脏和肾脏中,Anidulafungin呈剂量依赖性地显著降低真菌负荷。生物测定结果显示,于治疗的第5天,Anidulafungin的血清水平超过所有菌株相应的最低有效浓度。

注意事项

请于室内测试所有化合物的溶解度。虽然化合物的实际溶解度可能与其理论值略有不同,但仍处于实验系统误差的允许范围内。

References:

[1]. Zhanel GG1, Karlowsky JA, Harding GA, Balko TV, Zelenitsky SA, Friesen M, Kabani A, Turik M, Hoban DJ. In vitro activity of a new semisynthetic echinocandin, LY-303366, against systemic isolates of Candida species, Cryptococcus neoformans, Blastomyces dermatitidis, and Aspergillus species. Antimicrob Agents Chemother. 1997 Apr;41(4):863-5.

[2]. Calvo E, Pastor FJ, Mayayo E, Salas V, Guarro J. In vitro activity and in vivo efficacy of anidulafungin in murine infections by Aspergillus flavus. Antimicrob Agents Chemother. 2011 Mar;55(3):1290-2.

质量控制

化学结构

Anidulafungin

相关生物数据

Anidulafungin