Andarine
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Andarine(S-4)是一种选择性的AR抑制剂,Ki值为4 nM[1]。
雄激素受体(AR),也称作核受体亚家族3组C成员4,是一种核受体,在调控基因表达的DNA结合转录因子中扮演重要角色[2]。
Andarine是一种有效的AR抑制剂,比已报道的AR抑制剂S-1、S-2和S-3亲和力更高。通过共转染体系测定,浓度为10 nM的Andarine可刺激93%的AR介导的转录[1]。
在雄性Sprague-Dawley大鼠模型中,施用Andarine可通过剂量依赖的方式使前列腺、精囊和肛提肌生长,使其重量相对对照最大提高分别为33.8、28.2和101%。其对前列腺、精囊和肛提肌生长的ED50值分别为0.43±0.01、0.55±0.02和0.14±0.01 mg/日[1]。
参考文献:
[1]. Yin, D., et al., Pharmacodynamics of selective androgen receptor modulators. J Pharmacol Exp Ther, 2003. 304(3): p. 1334-40.
[2]. Thevis, M., et al., Mass spectrometric characterization of urinary metabolites of the selective androgen receptor modulator S-22 to identify potential targets for routine doping controls. Rapid Commun Mass Spectrom, 2011. 25(15): p. 2187-95.
Physical Appearance | A solid |
Storage | Store at -20°C |
M.Wt | 441.36 |
Cas No. | 401900-40-1 |
Formula | C19H18F3N3O6 |
Solubility | ≥21 mg/mL in DMSO; insoluble in H2O; ≥29.15 mg/mL in EtOH |
Chemical Name | (2S)-3-(4-acetamidophenoxy)-2-hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide |
SDF | Download SDF |
Canonical SMILES | C(=O)NC1=CC=C(C=C1)OCC(C)(C(=O)NC2=CC(=C(C=C2)[N+](=O)[O-])C(F)(F)F)O |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |
Description | Andarine是一种选择性的非甾体类雄激素受体(AR)拮抗剂,Ki值为4 nM。 | |||||
靶点 | androgen receptor | |||||
IC50 | 4 nM (Ki) |
质量控制和MSDS
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