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α-Amyloid Precursor Protein ModulatorPKC激活剂

α-Amyloid Precursor Protein Modulator

产品编号:B7842
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规格 单价 库存 订购数量
1mg ¥1,860.00 10-15 工作日发货

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Sample solution is provided at 25 µL, 10mM.

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化学性质

CAS号 497259-23-1 SDF Download SDF
化学名 (2E,4E)-N-(5-(hydroxymethyl)-2-isopropyl-1-methyl-3-oxo-1,2,3,4,5,6-hexahydrobenzo[e][1,4]diazocin-8-yl)-5-(4-(trifluoromethyl)phenyl)penta-2,4-dienamide
SMILES CC(C1C(NC(CO)CC2=C(C=CC(NC(/C=C/C=C/C3=CC=C(C(F)(F)F)C=C3)=O)=C2)N1C)=O)C
分子式 C27H30F3N3O3 分子量 501.54
溶解度 Soluble in DMSO 储存条件 Store at -20°C
运输条件 试用装:蓝冰运输。
其他可选规格:常温运输或根据您的要求用蓝冰运输。
一般建议 为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。

产品描述

α-Amyloid Precursor Protein Modulator is a benzolactam derived PKC activator.

Protein kinase C (PKC) belongs to a family of protein kinase enzymes involved in phosphorylating serine and threonine of other proteins. The PKC enzymes have been involved in regulating the function of other proteins. Protein kinase C plays an important role in several signal transduction cascades. Protein kinase C has been involved in modulating membrane structure events, mediating immune responses, regulating transcription, learning and memory, and regulating cell growth [2].

α-Amyloid Precursor Protein Modulator activated PKC with the Ki value of 11.9 nM for PKCα that efficiently enhanced non-amyloidogenic α-processing of amyloid precursor protein (APP) even at 100 nM in human fibroblast AG06848. α-Amyloid Precursor Protein Modulator displayed a marked loss of tumor promoting activity [1].

References:
[1] Kozikowski A P, Nowak I, Petukhov P A, et al.  New amide-bearing benzolactam-based protein kinase C modulators induce enhanced secretion of the amyloid precursor protein metabolite sAPPα[J]. Journal of medicinal chemistry, 2003, 46(3): 364-373.
[2] Stabel S, Parker P J.  Protein kinase C[J]. Pharmacology & therapeutics, 1991, 51(1): 71-95.