Amyloid Precursor C-Terminal Peptide
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
淀粉样前体C-端肽（APP）（C86H118N20O27S）的氨基酸序列为Gly-Tyr-Glu-Asn-Pro-Thr-Tyr-Lys-Phe-Phe-Glu-Gln-Met-Gln-Asn。尽管它可作为突触形成、神经可塑性和铁输出的调节子，但APP最重要的功能是作为前体分子，其蛋白水解产生β淀粉样蛋白（Aβ），一个含37-49个氨基酸的多肽。Aβ的淀粉样原纤维形式是阿尔茨海默病患者脑中发现的淀粉样蛋白斑块的主要成分。因此，Aβ可能通过MAPKs和NF-κB依赖的星形胶质细胞增生，造成阿尔茨海默病的发病。最近发现，APP与关节炎动物相关，诱导继发炎症，可能引起局部损伤。
参考文献：
1. Priller C, Bauer T, Mitteregger G, Krebs B, Kretzschmar HA, Herms J (July 2006). "Synapse formation and function is modulated by the amyloid precursor protein". J. Neurosci. 26 (27): 7212–21.
2. Turner PR, O'Connor K, Tate WP, Abraham WC (May 2003). "Roles of amyloid precursor protein and its fragments in regulating neural activity, plasticity and memory". Prog. Neurobiol. 70 (1): 1–32.
3. Duce JA et al (2010). "Iron-Export Ferroxidase Activity of β- Amyloid Precursor Protein Is Inhibited by Zinc in Alzheimer's Disease". Cell 142 (6): 857–67.
4. Subramanian S (January 2010). "Immunological and Biochemical factors in amyloidosis of adjuvant arthritic rats". Asian Journal of Experimental Biological Sciences 24 (1): 101–105.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 1896.04 |
| Formula | C86H118N20O27S1 |
| Synonyms | H2N-Gly-Tyr-Glu-Asn-Pro-Thr-Tyr-Lys-Phe-Phe-Glu-Gln-Met-Gln-Asn-OH |
| Solubility | ≥189.6 mg/mL in DMSO; insoluble in EtOH; ≥10.92 mg/mL in H2O |
| SDF | Download SDF |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
质量控制和MSDS
- 批次:
化学结构
