Amyloid Beta-Peptide (12-28) (human)
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
β淀粉样蛋白(Aβ或Abeta)是由淀粉样前体蛋白加工得到的多肽,含有36-43个氨基酸。众所周知,它是与阿尔茨海默病相关的淀粉样蛋白斑的成分,研究表明,Aβ是一个高度多功能的多肽,具有显著的非病理性活性(1)。Aβ是在阿尔茨海默病患者的脑中发现的沉积物的主要成分。阿尔茨海默病患者脑中Aβ含量升高。 Aβ是脑实质和血管淀粉样蛋白的主要成分,它有助于脑血管病变和神经毒性(2)。
Figure1 Formula of Amyloid β-Peptide (12-28) (human)
Figure2 signal pathway of Amyloid β
参考文献:
1. Lahiri DK, Maloney B (September 2010). "Beyond the signaling effect role of amyloid–β42 on the processing of AβPP, and its clinical implications". Exp. Neurol. 225 (1): 51–4.
2. Hardy J, Duff K, Hardy KG, Perez-Tur J, Hutton M (September 1998). "Genetic dissection of Alzheimer's disease and related dementias: amyloid and its relationship to tau". Nat. Neurosci. 1 (5): 355–8.
Physical Appearance | A solid |
Storage | Desiccate at -20°C |
M.Wt | 1955.2 |
Cas No. | 107015-83-8 |
Formula | C89H135N25O25 |
Synonyms | Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys |
Solubility | ≥195.5 mg/mL in DMSO; insoluble in EtOH; ≥59.8 mg/mL in H2O |
SDF | Download SDF |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |
质量控制和MSDS
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