Amlodipine Besylate
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Amlodipine Besylate是一种长效钙通道阻滞剂,能够降低血压,用作降压药.
钙通道是一种离子通道,选择性地使钙离子通过,在细胞信号转导中起着重要作用.
在皮层神经元中,Amlodipine Besylate(<= 5 μM)解救H2O2损伤细胞的活力并提升自由基水平.Amlodipine Besylate具有神经保护作用,如减少氧化应激\促进存活信号以及阻断死亡信号[1].Amlodipine Besylate还促进人类表皮样癌A431细胞增殖[2].
在劳累性心绞痛患者中,Amlodipine Besylate减少总外周阻力与心肌需氧量.在猫中,每日口服给予Amlodipine Besylate间接地降低了平均收缩压,而不会显著地改变体重\血清肌酐浓度以及钾浓度[3].
参考文献:
[1] Lee YJ, Park HH, Koh SH, Choi NY, Lee KY. Amlodipine besylate and amlodipine camsylate prevent cortical neuronal cell death induced by oxidative stress. J Neurochem. 2011 Dec;119(6):1262-70. doi: 10.1111/j.1471-4159.2011.07529.x.
[2] Yoshida J, Ishibashi T, Nishio M. Antiproliferative effect of Ca2+ channel blockers on human epidermoid carcinoma A431 cells. Eur J Pharmacol. 2003 Jul 4;472(1-2):23-31.
[3] Henik RA, Snyder PS, Volk LM. Treatment of systemic hypertension in cats with amlodipine besylate. J Am Anim Hosp Assoc. 1997 May-Jun;33(3):226-34.
Physical Appearance | A solid |
Storage | Store at -20°C |
M.Wt | 567.05 |
Cas No. | 111470-99-6 |
Formula | C20H25ClN2O5·C6H6O3S |
Solubility | ≥26.05 mg/mL in DMSO; insoluble in H2O; ≥11.26 mg/mL in EtOH with ultrasonic |
Chemical Name | benzenesulfonic acid;3-O-ethyl 5-O-methyl 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate |
SDF | Download SDF |
Canonical SMILES | CCOC(=O)C1=C(NC(=C(C1C2=CC=CC=C2Cl)C(=O)OC)C)COCCN.C1=CC=C(C=C1)S(=O)(=O)O |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |
质量控制和MSDS
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