AM 1172
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
AM 1172是一种有效的稳定大麻素摄取的选择性抑制剂，IC50值为2.1 - 2.5 μM，也是脂肪酸酰胺水解酶（FAAH）抑制剂，Ki值为3.18 μM。
FAAH是丝氨酸水解酶家族的成员，是一种整合膜水解酶，可水解生物活性酰胺，包括将大麻素水解为游离脂肪酸和乙醇胺。在体外，FAAH具有酯酶和酰胺酶活性。在体内，该蛋白是用于分解称作脂肪酸酰胺（FAA）的生物活性脂类的主要分解酶。
在啮齿类大脑皮层神经元和人类星形细胞瘤细胞中，AM1172可阻断[3H]大麻素的内化，而非充当FAAH的抑制剂[1]。在小鼠大脑皮层神经细胞中，该物质也可阻断氚标记的AEA吸收，EC50值约为1.5 μM[1]。
关于AM 1172的体内效果，在人类或小鼠或其他动物模型中的研究仍待进行以提供相关证据。
参考文献：
1. Fegley D, Kathuria S, Mercier R, et al. Anandamide transport is independent of fatty-acid amide hydrolase activity and is blocked by the hydrolysis-resistant inhibitor AM1172. Proceedings of the National Academy of Sciences of the United States of America. 2004;101(23):8756-8761.
| Physical Appearance | A solution in ethanol |
| Storage | Store at -20°C |
| M.Wt | 409.6 |
| Cas No. | 251908-92-6 |
| Formula | C27H39NO2 |
| Solubility | Soluble in ethanol |
| Chemical Name | 4-hydroxy-N-((5E,8E,11E,14E)-icosa-5,8,11,14-tetraen-1-yl)benzamide |
| SDF | Download SDF |
| Canonical SMILES | O=C(C(C=C1)=CC=C1O)NCCCC/C=C/C/C=C/C/C=C/C/C=C/CCCCC |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
化学结构
