AM-095 free base
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
AM095是新型的、有效的和口服的溶血磷脂酸受体1（LPA1）拮抗剂，对重组人和小鼠LPA1的IC50值分别为0.98和0.73 μM[1]。
在小鼠LPA1/CHO细胞和人A2058黑色素瘤细胞中，AM095体外抑制LPA1诱导的趋化性，其IC50值分别为0.78 μM和0.23μM[1]。
在小鼠体内，AM095剂量依赖性地阻断LPA诱导的组胺释放，其ED50值为8.3 mg/kg。此外，在肺部中，AM095显著降低支气管肺泡灌洗液中的胶原和蛋白，其ED50值为10 mg/kg。在小鼠中，AM095也减少Bleomycin诱导的巨噬细胞和淋巴细胞浸润[1]。
参考文献：
[1] Swaney JS1, Chapman C, Correa LD, Stebbins KJ, Broadhead AR, Bain G, Santini AM, Darlington J, King CD, Baccei CS, Lee C, Parr TA, Roppe JR, Seiders TJ, Ziff J, Prasit P, Hutchinson JH, Evans JF, Lorrain DS. Pharmacokinetic and pharmacodynamic characterization of an oral lysophosphatidic acid type 1 receptor-selective antagonist. J Pharmacol Exp Ther. 2011 Mar;336(3):693-700.
| Storage | Store at -20°C |
| M.Wt | 456.49 |
| Cas No. | 1228690-36-5 |
| Formula | C27H24N2O5 |
| Synonyms | AM 095;AM095 |
| Solubility | insoluble in EtOH; ≥42 mg/mL in DMSO; ≥8.12 mg/mL in H2O with ultrasonic |
| Chemical Name | 2-[4-[4-[3-methyl-4-[[(1R)-1-phenylethoxy]carbonylamino]-1,2-oxazol-5-yl]phenyl]phenyl]acetic acid |
| SDF | Download SDF |
| Canonical SMILES | CC1=NOC(=C1NC(=O)OC(C)C2=CC=CC=C2)C3=CC=C(C=C3)C4=CC=C(C=C4)CC(=O)O |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
| Description | AM095是有效的LPA1受体拮抗剂，对重组人和小鼠LPA1的IC50值分别为0.98和0.73 μM。 | |||||
| 靶点 | LPA1 receptor | |||||
| IC50 | 0.98 μM (recombinant human) 0.73 μM (recombinant mouse) | |||||
质量控制和MSDS
- 批次:
化学结构
