Alogliptin Benzoate
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
阿格列汀(alogliptin)是一种新型的、高选择性的及强效的丝氨酸蛋白酶二肽基肽酶-4 (DPP-4)抑制剂,IC50值小于10 nM [1]。
有报道称,在ob/ob小鼠中,阿格列汀可显著降低血浆DPP-4活性,剂量依耐性地增加活性GLP-1水平。此外,阿格列汀给药4周后可显著减少非空腹糖化血红蛋白、非空腹血糖及甘油三酯水平,以及显著增加ob/ob小鼠内非空腹血浆胰岛素及空腹胰腺胰岛素含量。另外,阿格列汀处理的ob/ob小鼠早期胰岛素分泌增加,血糖AUC减少[2]。
参考文献:
[1] Feng J,Zhang Z,Wallace MB,Stafford JA,Kaldor SW,Kassel DB,Navre M,Shi L,Skene RJ,Asakawa T,Takeuchi K,Xu R,Webb DR,Gwaltney SL 2nd. Discoveryofalogliptin: apotent,selective,bioavailable, andefficaciousinhibitorofdipeptidylpeptidaseIV. J Med Chem.2007 May 17;50(10):2297-300.
[2] Moritoh Y1,Takeuchi K,Asakawa T,Kataoka O,Odaka H. Chronic administration of alogliptin, a novel, potent, and highly selective dipeptidyl peptidase-4 inhibitor, improves glycemic control and beta-cell function in obese diabetic ob/ob mice. Eur J Pharmacol.2008 Jul 7;588(2-3):325-32.
Physical Appearance | A solid |
Storage | Store at -20°C |
M.Wt | 461.51 |
Cas No. | 850649-62-6 |
Formula | C25H27N5O4 |
Synonyms | SYR322, SYR-322,Nesina; |
Solubility | ≥46.2 mg/mL in DMSO; ≥3.02 mg/mL in EtOH with gentle warming and ultrasonic; ≥46.2 mg/mL in H2O with gentle warming |
Chemical Name | 2-[[6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-dioxopyrimidin-1-yl]methyl]benzonitrile;benzoic acid |
SDF | Download SDF |
Canonical SMILES | CN1C(=O)C=C(N(C1=O)CC2=CC=CC=C2C#N)N3CCCC(C3)N.C1=CC=C(C=C1)C(=O)O |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |
Description | 苯甲酸阿格列汀(alogliptin benzoate) (SYR 322)是一种强效的、选择性的DPP-4抑制剂,IC50值小于10 nM,其对DPP-4的选择性比对DPP-8和DPP-9高10,000倍以上。 | |||||
靶点 | DPP-4 | |||||
IC50 | <10 nM |
质量控制和MSDS
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