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Alfacalcidol

现货
Catalog No.
B2153
骨吸收抑制剂
组合的产品项目
规格价格库存 数量
10mM (in 1mL DMSO)
¥ 1,330.00
现货
5mg
¥ 850.00
现货
10mg
¥ 1,400.00
现货
25mg
¥ 2,600.00
现货
100mg
¥ 6,800.00
Ship with 10-15 days
500mg
¥ 26,130.00
Ship with 10-15 days

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Background

Alfacalcidol is an analogue of Vitamin D and a potent inhibitor of bone resorption [1].

Alfacalcidol has been revealed to play a part in bone and mineral homeostasis via binding to the VDR (vitamin D receptor) in calcium-related target organs, such as intestine, bone, kidney and parathyroid gland. In addition, in a high bone-turnover state after OVX, Alfacalcidol has been reported to inhibit osteoclastic bone resorption at pharmacological doses that do not cause hypercalcemia. Apart from these, Alfacalcidol has shown the stimulative effect to the bone formation. Furthermore, Alfacalcidol has been found to enhance bone mass and bone strength at given serum and urinary calcium levels in the OVX model.

References:
[1] Shiraishi A1, Takeda S, Masaki T, Higuchi Y, Uchiyama Y, Kubodera N, Sato K, Ikeda K, Nakamura T, Matsumoto T, Ogata E. Alfacalcidol inhibits bone resorption and stimulates formation in an ovariectomized rat model of osteoporosis: distinct actions from estrogen. J Bone Miner Res. 2000 Apr;15(4):770-9.

Chemical Properties

Physical AppearanceA solid
StorageStore at -20°C
M.Wt400.65
Cas No.41294-56-8
FormulaC27H44O2
Solubility≥20.05mg/mL in DMSO
Chemical Name(1R,3S,5E)-5-[(2Z)-2-[(1R,3aS,7aR)-7a-methyl-1-[(2R)-6-methylheptan-2-yl]-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol
SDFDownload SDF
Canonical SMILESCC(C)CCCC(C)C1CCC2C1(CCCC2=CC=C3CC(CC(C3=C)O)O)C
运输条件试用装:蓝冰运输。 其他可选规格:常温运输或根据您的要求用蓝冰运输。
一般建议为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。

试验操作

动物实验[1]:

动物模型

卵巢切除大鼠骨质疏松模型

溶解方法

在DMSO中的溶解度>20.1mg/mL。为了获得更高的浓度,可以将离心管在37℃加热10分钟和/或在超声波浴中震荡一段时间。原液可以在-20℃以下储存几个月。

剂量

0.05, 0.1和0.2 μg/kg;口服给药;每周5次,给药12周

应用

在卵巢切除大鼠骨质疏松模型中,Alfacalcidol以剂量依赖的方式抑制破骨细胞骨吸收,维持甚至刺激骨形成。Alfacalcidol比17b-雌二醇更有效地增加骨矿物质密度和改善机械强度。

注意事项

请测试所有化合物在室内的溶解度,实际溶解度和理论值可能略有不同,这是由实验系统的误差引起的,属于正常现象。

References:

[1] Shiraishi A1, Takeda S, Masaki T, Higuchi Y, Uchiyama Y, Kubodera N, Sato K, Ikeda K, Nakamura T, Matsumoto T, Ogata E. Alfacalcidol inhibits bone resorption and stimulates formation in an ovariectomized rat model of osteoporosis: distinct actions from estrogen. J Bone Miner Res. 2000 Apr;15(4):770-9.

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