AL 8697
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
AL8697是p38 MAPK(促分裂原活化蛋白激酶)的选择性抑制剂,也称P38 α抑制剂。该物质具有抑制P38 MAPK活性的功能。[1]
促分裂原活化蛋白激酶(MAPK)是一类信号分子,在炎症过程中扮演重要角色。P38 MAPK是研究最为详尽的MAPK级联之一。p38 MAPK在单核细胞/巨噬细胞产生促炎细胞因子如TNFa和IL-6的合成和信号通路中扮演关键角色。p38 MAPK参与小鼠巨噬细胞TNF合成的上调。p38 MAPK在多种细胞压力下的心血管细胞中具有高活性。在心血管疾病中,P38 MAPK信号通路被活化。[2,3]
AL8697通过抑制P38 MAPK发挥作用。该物质可调节多种与P38 MAPK相关的细胞活性。
在大鼠免疫佐剂诱导的关节炎模型中,AL8697具有良好的抗炎作用,并可诱导白细胞增多,增加总血浆胆固醇,这些特性在10 mg/kg下十分明显。此外,AL8697可部分恢复血小板计数。AL8697在大鼠AIA(免疫佐剂诱导的关节炎)中的复杂特性并未在人类RA(类风湿关节炎)中观察到。[1]
参考文献:
[1]. Balagué C, Pont M, Prats N, Godessart N. Profiling of dihydroorotate dehydrogenase, p38 and JAK inhibitors in the rat adjuvant-induced arthritis model: a translational study. Br J Pharmacol. 2012 Jun;166(4):1320-32
[2]. Ajizian SJ, English BK, Meals EA.Specific inhibitors of p38 and extracellular signal-regulated kinase mitogen-activated protein kinase pathways block inducible nitric oxide synthase and tumor necrosis factor accumulation in murine macrophages stimulated with lipopolysaccharide and interferon-gamma. J Infect Dis. 1999 Apr;179(4):939-44.
[3]. Bao W, Behm DJ, Nerurkar SS, Ao Z, et al. Effects of p38 MAPK Inhibitor on angiotensin II-dependent hypertension, organ damage, and superoxide anion production. J Cardiovasc Pharmacol. 2007 Jun;49(6):362-8.
Physical Appearance | White solid |
Storage | Store at -20°C |
M.Wt | 402.41 |
Cas No. | 1057394-06-5 |
Formula | C21H21F3N4O |
Solubility | <40.24mg/ml in DMSO; <20.12mg/ml in ethanol |
Chemical Name | 3-(3-(tert-butyl)-6,8-difluoro-[1,2,4]triazolo[4,3-a]pyridin-7-yl)-N-cyclopropyl-5-fluoro-4-methylbenzamide |
SDF | Download SDF |
Canonical SMILES | FC1=C(C)C(C2=C(F)C3=NN=C(C(C)(C)C)N3C=C2F)=CC(C(NC4CC4)=O)=C1 |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |