AIM-100
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
AIM-100是一种小分子Ack1酪氨酸激酶抑制剂，IC50值为24 nM[1]。
AIM-100模仿ATP，且显著地、特异性抑制Ack1活性。AIM-100对其他30个激酶（包括PI3-激酶和AKT）无抑制活性，且其对Lck具有5倍更高的IC50值。在EGF处理的MEF细胞中，AIM-100显著降低Ack1活性。在人前列腺癌细胞LNCaP和LAPC4中，AIM-100用药可导致G0/G1期细胞数量增加及随后的细胞生长抑制。AIM-100的这些效果对胰腺癌细胞也同样起作用。AIM-100在10 μM浓度时诱发Panc-1细胞的凋亡。此外，AIM-100抑制细胞生长，在CD-18、Panc-1、OV90、MCF-7及MDA-MB-468癌细胞中的GI50值在7到8 μM范围内[1, 2]。
参考文献：
1. Mahajan K, Challa S, Coppola D, et al. Effect of Ack1 tyrosine kinase inhibitor on ligand-independent androgen receptor activity. The Prostate, 2010, 70(12): 1274-1285.
2. Mahajan K, Coppola D, Chen Y, et al. Ack1 tyrosine kinase activation correlates with pancreatic cancer progression. The American journal of pathology, 2012, 180(4): 1386-1393.
| Storage | Store at -20°C |
| M.Wt | 371.43 |
| Cas No. | 873305-35-2 |
| Formula | C23H21N3O2 |
| Synonyms | AIM 100;AIM100 |
| Solubility | insoluble in H2O; ≥35.8 mg/mL in EtOH with gentle warming; ≥36 mg/mL in DMSO with gentle warming |
| Chemical Name | N-[[(2S)-oxolan-2-yl]methyl]-5,6-diphenylfuro[2,3-d]pyrimidin-4-amine |
| SDF | Download SDF |
| Canonical SMILES | C1CC(OC1)CNC2=C3C(=C(OC3=NC=N2)C4=CC=CC=C4)C5=CC=CC=C5 |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
质量控制和MSDS
- 批次:
化学结构
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