AICAR phosphate
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
AICAR phosphate(Acadesine)是一种AMPK激活剂[1].
B-CLL细胞活力试验表明,AICAR phosphate呈剂量依赖性地诱导细胞凋亡,其EC50值为380 ± 60 μM.在B-CLL细胞中,AICAR phosphate诱导caspase激活,并促进细胞色素c从线粒体释放.此外,AICAR phosphate(2 ~ 4 mM)对来源于B-CLL患者的T细胞活力仅有微弱影响.因此,AICAR phosphate(0.5 mM)显着减少B细胞活力,而对T细胞影响不大[1].
参考文献：
[1] Campàs C1, Lopez JM, Santidrián AF, Barragán M, Bellosillo B, Colomer D, Gil J. Acadesine activates AMPK and induces apoptosis in B-cell chronic lymphocytic leukemia cells but not in T lymphocytes. Blood. 2003 May 1;101(9):3674-80. Epub 2003 Jan 9.
| Storage | Store at -20°C |
| M.Wt | 356.23 |
| Cas No. | 681006-28-0 |
| Formula | C9H17N4O9P |
| Solubility | Soluble in DMSO |
| Chemical Name | 5-amino-1-(3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1H-imidazole-4-carboxamide phosphate |
| SDF | Download SDF |
| Canonical SMILES | C1=NC(=C(N1C2C(C(C(O2)CO)O)O)N)C(=O)N.OP(=O)(O)O |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
化学结构
