Agomelatine
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Agomelatine是一种褪黑激素受体激动剂和血清素5-HT2C受体拮抗剂,对MT1和MT2的Ki值分别为0.062 nM和0.268 nM,对5-HT2C的IC50值为0.27 μM[1].
Agomelatine是一种独特的抗抑郁剂,主要开发用于重度抑郁症(MDD)的治疗.Agomelatine是一种选择性5-HT2C拮抗剂.它对克隆的人5-HT2A和5-HT1A具有较低亲和力.对褪黑激素受体MT1和MT2,agomelatine显示出相似的亲和力,Ki分别为0.09 nM和0.263 nM.在体内试验中,agomelatine通过阻断5-HT2C的抑制性输入,导致多巴胺和去甲肾上腺素水平升高.而且,在抑郁症大鼠模型中,agomelatine阻碍压力诱导的蔗糖消耗下降.除此之外,agomelatine对焦虑症啮齿动物模型产生缓解焦虑的疗效[1].
参考文献：
[1] Zupancic M, Guilleminault C. Agomelatine. CNS drugs, 2006, 20(12): 981-992.
| Storage | Store at -20°C |
| M.Wt | 243.3 |
| Cas No. | 138112-76-2 |
| Formula | C15H17NO2 |
| Solubility | insoluble in H2O; ≥117.6 mg/mL in EtOH; ≥12.17 mg/mL in DMSO |
| Chemical Name | N-[2-(7-methoxynaphthalen-1-yl)ethyl]acetamide |
| SDF | Download SDF |
| Canonical SMILES | CC(=O)NCCC1=CC=CC2=C1C=C(C=C2)OC |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
质量控制和MSDS
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化学结构
