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AEG 3482

现货
Catalog No.
B9010
Jun激酶(JNK)依赖性细胞凋亡抑制剂
组合的产品项目
规格价格库存 数量
10mM (in 1mL DMSO)
¥ 700.00
现货
10mg
¥ 1,190.00
现货

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Background

AEG3482 is a small-molecule inhibitor of Jun kinase (JNK)-dependent apoptosis. [1,2]

Jun kinases, also called Jun N-terminal kinase stress-activated protein kinases. Activation of the JNK signaling pathway is a major event in neuronal apoptosis. This is proved by pathological specimens from Alzheimer’s disease, as well as samples from mouse models of Alzheimer’s and Huntington’s disease, reveal activated JNK. [2]

AEG3482 blocks apoptosis induced by the p75 neurotrophin receptor (p75NTR) or NRAGE, which is p75NTR’s cytosolic interactor,. AEG3482 inhibits proapoptotic JNK activity. AEG3482 induces production of heat shock protein 70 (HSP70) which is an endogenous inhibitor of JNK. HSP70 accumulation is required for the AEG3482-induced JNK blockade. [1]

As described, activation of C-jun N-terminal kinase (JNK) signaling is associated with neuronal cell death. AEG3482 interacts with heat shock protein 90 leading to inhibition of JNK and blockade of neuronal apoptosis. So AEG3482 can serve as useful tools for basic research, and it may have therapeutic potential for the treatment of acute and chronic neurological disorders. In the neuropathologicalstate, the chaperone-mediated stress response may be primed for response to Hsp90 inhibitors; and AEG3482, may be selective neuroprotective agents.[1,2]

References:
[1]Salehi AH, Morris SJ, Ho WC, etal. , AEG3482 is an antiapoptotic compound that inhibits Jun kinase activity and cell death through induced expression of heat shock protein 70. Chem Biol. 2006 Feb;13(2):213-23.
[2] Gallo KA.   Targeting HSP90 to halt neurodegeneration. Chem Biol. 2006 Feb;13(2):115-6.

Chemical Properties

Physical AppearanceA solid
StorageStore at RT
M.Wt280.33
Cas No.63735-71-7
FormulaC10H8N4O2S2
Solubility≥14mg/mL in DMSO
Chemical Name6-phenylimidazo[2,1-b][1,3,4]thiadiazole-2-sulfonamide
SDFDownload SDF
Canonical SMILESNS(C1=NN(C(S1)=N2)C=C2C3=CC=CC=C3)(=O)=O
运输条件试用装:蓝冰运输。 其他可选规格:常温运输或根据您的要求用蓝冰运输。
一般建议为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。

试验操作

细胞实验[1]:

细胞系

PC12神经细胞

溶解方法

在DMSO中的溶解度大于14 mg/mL。为了获得更高的浓度,可以将离心管在37℃加热10分钟和/或在超声波浴中震荡一段时间。原液可以在-20℃以下储存几个月。

反应条件

10、20和40 μM,18 h

应用

AEG 3482是一个有效的抗凋亡化合物。在PC12神经细胞中,AEG 3482抑制促凋亡JNK的活性,阻断p75NTR和NRAGE诱导的细胞凋亡。AEG 3482通过增加HSP70的表达抑制JNK通路。

References:

[1]. Salehi A H, Morris S J, Ho W C, et al. AEG3482 is an antiapoptotic compound that inhibits Jun kinase activity and cell death through induced expression of heat shock protein 70[J]. Chemistry & biology, 2006, 13(2): 213-223.

质量控制

化学结构

(-)-epicatechin gallate