Adrenorphin
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Adrenorphin(metorphamide)是一种有效的尼古丁诱导肾上腺素和去甲肾上腺素释放抑制剂,IC50值为10 μM[1]。
Adrenorphin(metorphamide)是脑啡肽原A经蛋白水解而产生的内源性的、C端酰胺化的阿片八肽(Tyr-Gly-Gly-Phe-Met-Arg-Arg-Val-NH2),在哺乳动物大脑中广泛分布[2]。
Adrenorphin(metorphamide)是一种选择性的尼古丁诱导肾上腺素和去甲肾上腺素释放抑制剂,比已报导的尼古丁诱导肾上腺素和去甲肾上腺素释放抑制剂Met5-enkephalin强效100多倍。在牛肾上腺髓质细胞中,浓度为5 μM的adrenorphin(metorphamide)对5 μM尼古丁诱导的ATP释放表现出将近50%的抑制,且不呈现剂量依赖特征[1]。在生物实验和结合实验中,metorphamide具有较高的μ-结合活性,以及μ-结合活性一半的κ-结合活性,而不呈现δ-结合活性[2]。
参考文献:
[1]. Marley, P.D., K.I. Mitchelhill, and B.G. Livett, Metorphamide, a novel endogenous adrenal opioid peptide, inhibits nicotine-induced secretion from bovine adrenal chromaffin cells. Brain Res, 1986. 363(1): p. 10-7.
[2]. Weber, E., et al., Metorphamide: isolation, structure, and biologic activity of an amidated opioid octapeptide from bovine brain. Proc Natl Acad Sci U S A, 1983. 80(23): p. 7362-6.
Physical Appearance | A solid |
Storage | Store at -20°C |
M.Wt | 984.18 |
Cas No. | 88377-68-8 |
Formula | C44H69N15O9S |
Synonyms | H2N-Tyr-Gly-Gly-Phe-Met-Arg-Arg-Val-amide |
Solubility | insoluble in EtOH; ≥48.7 mg/mL in H2O; ≥98.4 mg/mL in DMSO |
Chemical Name | Adrenorphin |
SDF | Download SDF |
Canonical SMILES | CC(C)C(C(=O)N)NC(=O)C(CCCN=C(N)N)NC(=O)C(CCCN=C(N)N)NC(=O)C(CCSC)NC(=O)C(CC1=CC=CC=C1)NC(=O)CNC(=O)CNC(=O)C(CC2=CC=C(C=C2)O)N |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |
质量控制和MSDS
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