Adrenorphin, Free Acid
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Adrenorphin (有时也被称为metorphamide)是一个内生的C端酰胺化的类鸦片的八肽，它是由脑啡肽原的蛋白水解产生的，广泛分布在整个哺乳动物大脑里[1]。它是基于最初在来源于肾上腺髓质的人类嗜铬细胞瘤中发现而命名的，后来在正常人类和牛肾上腺髓质也发现了Adrenorphin。Adrenorphin具有有效的类鸦片活性，作为一个平衡的μ-和κ-opioid受体激动剂而对δ-opioid受体没有影响[2]。它具有镇痛和呼吸抑郁的特性[3]。
Figure 1 proteolytic cleavage of proenkephalin A
参考文献：
1. Matsuo H, Miyata A, Mizuno K (1983). "Novel C-terminally amidated opioid peptide in human phaeochromocytoma tumour". Nature 305 (5936): 721–3.
2. Weber E, Esch FS, Böhlen P et al. (December 1983). "Metorphamide: isolation, structure, and biologic activity of an amidated opioid octapeptide from bovine brain". Proceedings of the National Academy of Sciences of the United States of America 80 (23): 7362–6.
3. Xu SF, Lu WX, Zhou KR et al. (April 1985). "The analgesic and respiratory depressant actions of metorphamide in mice and rabbits". Neuropeptides 6 (2): 121–31.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 985.16 |
| Cas No. | 88866-92-6 |
| Formula | C44H68N14O10S |
| Synonyms | Adrenorphin, Free Acid,H2N-Tyr-Gly-Gly-Phe-Met-Arg-Arg-Val-OH |
| Solubility | ≥27.75 mg/mL in H2O with ultrasonic; ≥5.64 mg/mL in EtOH with ultrasonic; ≥98.5 mg/mL in DMSO |
| Chemical Name | 1-[[4-[2-(azepan-1-yl)ethoxy]phenyl]methyl]-2-(4-hydroxyphenyl)-3-methylindol-5-ol |
| SDF | Download SDF |
| Canonical SMILES | CC(C)C(C(=O)O)NC(=O)C(CCCN=C(N)N)NC(=O)C(CCCN=C(N)N)NC(=O)C(CCSC)NC(=O)C(CC1=CC=CC=C1)NC(=O)CNC(=O)CNC(=O)C(CC2=CC=C(C=C2)O)N |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
质量控制和MSDS
- 批次:
化学结构
