Adarotene
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
维甲酸相关分子是维甲酸的衍生物,且是有前途的抗白血病药物,具有不同于其他常见的化疗药物的作用机制。Adarotene是一种新型的非典型维甲酸,具有促凋亡和抗肿瘤活性。
体外:该新型非典型维甲酸adarotene对一系列人类肿瘤细胞有强效抗增殖活性。研究发现,尽管激活RARs的能力几乎完全丧失,adarotene作为一种有效的细胞凋亡诱导剂,且能出人意料地导致DNA损伤,这很可能有助于其促凋亡活性[1]。
体内:口服之后,adarotene耐受性良好,可引起卵巢癌(A2780/DX)和人黑色素瘤(MeWo)异种移植裸鼠中肿瘤生长抑制,支持了该新型制剂的治疗利益[1]。
临床试验:目前Adarotene仅处在临床前发展阶段,还没有临床数据。
参考文献:
[1] Cincinelli R, Dallavalle S, Merlini L, Penco S, Pisano C, Carminati P, Giannini G, Vesci L, Gaetano C, Illy B, Zuco V, Supino R, Zunino F. A novel atypical retinoid endowed with proapoptotic and antitumor activity. J Med Chem. 2003;46(6):909-12.
Physical Appearance | A solid |
Storage | Store at -20°C |
M.Wt | 374.47 |
Cas No. | 496868-77-0 |
Formula | C25H26O3 |
Synonyms | ST 1926;ST-1926;ST1926 |
Solubility | ≥37.4 mg/mL in DMSO; insoluble in H2O; ≥10.97 mg/mL in EtOH with gentle warming and ultrasonic |
Chemical Name | (E)-3-[4-[3-(1-adamantyl)-4-hydroxyphenyl]phenyl]prop-2-enoic acid |
SDF | Download SDF |
Canonical SMILES | C1C2CC3CC1CC(C2)(C3)C4=C(C=CC(=C4)C5=CC=C(C=C5)C=CC(=O)O)O |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |
Description | 作为RAR β和RAR γ的选择性激活剂,Adarotene是一种新型强效的促凋亡剂和细胞分化诱导剂。 | |||||
靶点 | RAR β | RAR γ | ||||
IC50 |
质量控制和MSDS
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