a-MSH, amide
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
α-MSH，酰胺（C77H109N21O19S1），序列为Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2，分子量为1664.9。促黑素细胞激素，统称为MS或intermedins，是一类由垂体中叶细胞产生的多肽激素。MSH的增加导致人变黑。怀孕期间促黑素增加，伴随着雌激素的增加，引起孕妇色素沉着增多。库欣综合征是由于过量促肾上腺皮质激素（ACTH）导致色素沉着过度，例如腋窝黑棘皮症。大多数患有原发性阿狄森氏症的患者皮肤变黑（色素沉着过度），包括不暴露在太阳的部位，特征是皮肤皱折（例如手中）、乳头及脸颊（颊粘膜）的内部，旧疤痕可能会变暗。这是因为促黑素（MSH）和促肾上腺皮质激素（ACTH）具有相同的前体分子阿黑皮素原（POMC）。
促黑素是黑皮质素的一员，包括促肾上腺皮质激素、α-促黑素细胞激素（α-MSH）、（β-MSH）和（γ-MSH），这几个多肽是由前体肽阿黑皮素原（POMC）裂解的产物。α-MSH是色素沉着中最重要的黑皮质素。
Figure1 Formula of a-MSH, amide
参考文献：
1. Hadley ME (Oct 2005). "Discovery that a melanocortin regulates sexual functions in male and female humans". Peptides 26 (10): 1687–9.
2. MillingtonGW (May 2006). "Proopiomelanocortin (POMC): the cutaneous roles of its melanocortin products and receptors". Clin. Exp. Dermatol. 31 (3): 407–12
3. MillingtonGW (2007). "The role of proopiomelanocortin (POMC) neurones in feeding behaviour". Nutr Metab (Lond) 4: 18.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 1664.9 |
| Cas No. | 581-05-5 |
| Formula | C77H109N21O19S1 |
| Synonyms | Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-amide |
| Solubility | insoluble in EtOH; ≥10.44 mg/mL in H2O with ultrasonic; ≥166.5 mg/mL in DMSO with gentle warming |
| SDF | Download SDF |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
| Animal experiment:[1] | |
|
Animal models |
IL-10-deficient mice |
|
Dosage form |
50 µg/0.2 ml saline Injected intraperitoneally |
|
Applications |
α-MSH given systemically effectively alleviated acute inflammatory reactions induced by an irritant (picryl chloride 0.5% in acetone) applied to the ear. The relative inhibition (percent of percent change) with α-MSH was virtually the same in both IL-10–deficient and in control animals (approximately 70%). α-MSH modulated all forms of inflammation by acting on peripheral inflammatory cells, glial inflammatory cells, and on central nervous system receptors that activate descending anti-inflammatory neural pathways. |
|
Note |
The technical data provided above is for reference only. |
|
References: 1. Lipton JM, Zhao H, Ichiyama T, et al. Mechanisms of antiinflammatory action of alpha-MSH peptides. In vivo and in vitro evidence. Annals of the New York Academy of Sciences, 1999, 885: 173-182. |
|
质量控制和MSDS
- 批次:
化学结构
相关生物数据
