A 844606
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
A 844606是α7烟碱型乙酰胆碱受体(nAChR)的强效选择性部分激动剂,IC50值为11 nM [1]。
α7 nAChR是烟碱型乙酰胆碱受体,位于脑、脾和淋巴结的淋巴细胞中。α7 nAChR在神经精神疾病的病理生理学中起重要作用,如阿尔茨海默氏病、精神分裂症、药物成瘾及抑郁[2]。
A 844606是α7 nAChR的强效选择性部分激动剂,对α7和α4β2的IC50值分别为11和大于30000 nM。在表达重组人和大鼠α7 nAChR受体的爪蟾卵母细胞中,A 844606表现出激动活性,EC50值分别为1.4和2.2 μM。在PC12细胞中,A 844606激活α7 nAChR受体,刺激ERK1/2磷酸化[1]。
在小鼠大脑中,A 844606表现出较高的摄取。在猴脑中,A 844606主要分布在丘脑和海马中,小脑中含量很低。此外,使用α7 nAChR激动剂SSR180711预处理减少了A 844606的含量[2]。
参考文献:
[1]. Briggs CA, Schrimpf MR, Anderson DJ, et al. alpha7 nicotinic acetylcholine receptor agonist properties of tilorone and related tricyclic analogues. Br J Pharmacol, 2008, 153(5): 1054-1061.
[2]. Toyohara J, Ishiwata K, Sakata M, et al. In vivo evaluation of alpha7 nicotinic acetylcholine receptor agonists [11C]A-582941 and [11C]A-844606 in mice and conscious monkeys. PLoS One, 2010, 5(2): e8961.
Physical Appearance | Yellow solid |
Storage | Store at -20°C |
M.Wt | 320.38 |
Cas No. | 861119-08-6 |
Formula | C20H20N2O2 |
Solubility | insoluble in ethanol |
Chemical Name | 2-((3aR,6aR)-5-methylhexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)-9H-xanthen-9-one |
SDF | Download SDF |
Canonical SMILES | O=C1C2=CC(N3C[C@@H](CN(C)C4)[C@H]4C3)=CC=C2OC5=CC=CC=C15 |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |