A 419259 trihydrochloride
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
A 419259 trihydrochloride是口服有效的Lck抑制剂,其IC50值为15 nM[1].
Lck属于src家族酪氨酸激酶.抑制Lck可以防止T细胞活化,因而用于治疗T-细胞相关疾病,如自身免疫与炎症性疾病.A 419259 trihydrochloride有效地抑制重组lck(64 ~ 509),其IC50值为15 nM.A 419259 trihydrochloride也是一种选择性抑制剂,对其它激酶无效,包括cMet\IGFR\PKC和PDGFR.在Jurkat细胞中,A 419259 trihydrochloride抑制IL-2生成,其IC50值为25 nM.此外,在小鼠中,A 419259 trihydrochloride抑制IL-2生成,其ED50值为2.5 mg/kg.A 419259 trihydrochloride还作用于抗原特异性T细胞免疫应答.体内试验表明,A 419259 trihydrochloride在给药初期可以抑制IFN-γ生成[1].
参考文献:
[1] Calderwood D J, Johnston D N, Munschauer R, et al. Pyrrolo [2, 3-d] pyrimidines containing diverse N-7 substituents as potent inhibitors of Lck. Bioorganic & medicinal chemistry letters, 2002, 12(12): 1683-1686.
Physical Appearance | A crystalline solid |
Storage | Store at -20°C |
M.Wt | 592 |
Cas No. | 1435934-25-0 |
Formula | C29H37Cl3N6O |
Solubility | Soluble in DMSO |
Chemical Name | 7-((1r,4r)-4-(4-methylpiperazin-1-yl)cyclohexyl)-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine trihydrochloride |
SDF | Download SDF |
Canonical SMILES | CN1CCN([C@@]2([H])CC[C@@](N3C=C(C(C3=NC=N4)=C4N)C5=CC=C(OC6=CC=CC=C6)C=C5)([H])CC2)CC1.Cl.Cl.Cl |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |