切换导航
关闭
  • 菜单
  • Setting

6-fluoro-DL-Tryptophan

 
Catalog No.
C5214
5-羟色胺(5-HT)合成抑制剂
组合的产品项目
规格价格库存 数量
100mg
¥ 1,516.00
Ship with 10-15 days
250mg
¥ 2,925.00
Ship with 10-15 days
500mg
¥ 3,954.00
Ship with 10-15 days

电话: 021-55669583

邮箱: sales@apexbio.cn

全球经销商

A

背景

6-fluoro-DL-Tryptophan is a serotonin (5-HT) synthesis inhibitor.

Serotonin or 5-hydroxytryptamine (5-HT), a monoamine neurotransmitter, is biochemically derived from tryptophan. Serotonin is primarily present in the gastrointestinal tract, blood platelets, and the central nervous system of animals. Serotonin is considered to be a contributor to feelings of well-being and happiness.

In vitro: The potential competition was investigated between L-tryptophan (TRP) and 6-fluoro-DL-tryptophan (6-F-TRP). In equilibrium dialysis experiments, albumin bound about 80% of TRP and 50% of 6-F-TRP. Competitive inhibition was assessed as the decrease in the apparent Ka of TRP in the presence of 6-F-TRP, with no modification of the N value [1].

In vivo: Rats werer administered 6-fluoro-DL-tryptophan (6F-Trp) and its neurochemical effects on central catechole and indole were evaluated. Results showed that neither norepinephrine nor dopamine and its major metabolites were affected by 6F-Trp. With regard to serotonin (5-HT), 6F-Trp could induce a transient depletion in all the studied brain areas, with a maximum of about 60-65% obtained between 1 and 3 hr. After 6 hr, 5-HT levels returned to control values. In addition, the 5-hydroxyindolacetic acid (5-HIAA) level was also reduced 3 hr after 6F-Trp administration. A large dose-dependent increase in tryptophan was seen in the four brain areas, mainly due to an inhibition of tryptophan incorporation into protein, as demonstrated by experiments with mouse neuroblastoma cells [2].

Clinical trial: So far, no clinical study has been conducted.

References:
[1] Chanut, E. ,Zini, R.,Trouvin, J.H., et al. Albumin binding and brain uptake of 6-fluoro-DL-tryptophan: Competition with L-tryptophan. Biochemical Pharmacology 44(10), 2082-2085 (1992).
[2] Chanut, E. ,Trouvin, J.H.,Bondoux, D., et al. Metabolism of 6-fluoro-DL-tryptophan and its specific effects on the rat brain serotoninergic pathway. Biochemical Pharmacology 45(5), 1049-1057 (1992).

化学属性

Physical AppearanceA crystalline solid
StorageStore at -20°C
M.Wt222.2
Cas No.7730-20-3
FormulaC11H11FN2O2
SynonymsDL-6-Fluorotryptophan,NSC 9364
Solubility≤0.1mg/ml in methanol;1mg/ml in acetic acid (2%)
Chemical Name6-fluoro-tryptophan
SDFDownload SDF
Canonical SMILESFC1=CC2=C(C(CC(N)C(O)=O)=CN2)C=C1
运输条件 蓝冰运输或根据您的需求运输。
一般建议不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。

质量控制

质量控制和MSDS

批次:

化学结构

6-fluoro-DL-Tryptophan