6-Bnz-cAMP sodium salt
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
6-Bnz-cAMP是一种选择性的PKA激活剂,调节PKA依赖的信号通路。
PKA包含一个进化上保守的cAMP结合结构域,充当分子开关,用于感知细胞内第二信使cAMP的水平,从而控制不同的生物学功能。CAMP应答元件结合蛋白(CREB)是已知的PKA的直接靶蛋白,PKA对CREB(pCREB)的磷酸化参与调节成骨细胞分化。
被6-Bnz-cAMP所激活的增殖信号通路涉及表皮生长因子受体和ERK1/2的激活。延长PKA依赖性ERK1/2激活的持续时间,将cAMP从增殖信号转换成抗增殖、促突起生长信号。
6-Bnz-cAMP不仅可以促进分化和矿化,还促进初始细胞的粘附。6-Bnz-cAMP能够诱导MC3T3-E1细胞的成骨分化。而且,6-Bnz-cAMP可能有易于组织工程聚合骨架系统的释放动力学,也可作为一种新型骨诱导生长因子,用于骨再生工程中骨组织的修复和再生。
参考文献:
[1]Lo KW, Kan HM, Ashe KM, Laurencin CT. The small molecule PKA-specific cyclic AMP analogue as an inducer of osteoblast-like cells differentiation and mineralization. J Tissue Eng Regen Med. 2012 Jan;6(1):40-8.
[2]Simone Kiermayer, Ricardo M. Biondi,etal., Epac Activation Converts cAMP from a Proliferative into a Differentiation Signal in PC12 Cells. Molecular Biology of the Cell. Vol. 16, 5639–5648, December 2005.
[3]Cheng X, Ji Z, Tsalkova T, Mei F. Epac and PKA: a tale of two intracellular cAMP receptors. Acta Biochim Biophys Sin (Shanghai). 2008 Jul;40(7):651-62.
Physical Appearance | A crystalline solid |
Storage | Store at -20°C |
M.Wt | 455.29 |
Cas No. | 1135306-29-4 |
Formula | C17H15N5NaO7P |
Solubility | Soluble in H2O |
Chemical Name | sodium (4aR,6R,7R,7aS)-6-(6-benzamido-9H-purin-9-yl)-7-hydroxytetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-2-olate 2-oxide |
SDF | Download SDF |
Canonical SMILES | O=C(NC1=NC=NC2=C1N=CN2[C@@H]3O[C@@](COP(O4)(O[Na])=O)([H])[C@]4([H])[C@H]3O)C5=CC=CC=C5 |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |