切换导航
关闭
  • 菜单
  • Setting

6-Aminonicotinamide

 
Catalog No.
C4497
6-磷酸葡萄糖酸脱氢酶抑制剂
组合的产品项目
规格价格库存 数量
500mg
¥ 531.00
现货
1g
¥ 945.00
现货

电话: 021-55669583

邮箱: sales@apexbio.cn

全球经销商

A

背景

Ki: 0.46 μM

6-Aminonicotinamide is a 6-phosphogluconate dehydrogenase inhibitor.

6-Phosphogluconate dehydrogenase, an enzyme in the pentose phosphate pathway, can produce ribulose 5-phosphate from 6-phosphogluconate. 6-Phosphogluconate dehydrogenase is also an oxidative carboxylase catalyzing the decarboxylating reduction of 6-phosphogluconate into ribulose 5-phosphate in the presence of NADP.

In vitro: 6-Aminonicotinamide could be metabolized to 6-amino-NAD(P+), a competitive inhibitor of NAD(P+)-requiring processes, especially the pentose phosphate pathway enzyme, 6-phosphogluconate dehydrogenase. Moreove, 6-aminonicotinamide as a single agent could cause a significant inhibition of glycolytic flux but had no effect on the pentose phosphate pathway. 31P-NMR studies of perifused RIF-1 cells indicated that 4 h of exposure to 6-aminonicotinamide was enough to cause significant accumulation of 6-phosphogluconate, the substrate for this enzyme [1].

In vivo: The influence of 6-aminonicotinamide on the G-6-P-DH- and 6-PG-DH-levels of the pentose phosphate pathway in the kidney was investigated. Following i.p. administration of 6-aminonicotinamide at 6 mg/kg, the 6-PG-level rose from a value less than 10 nmoles/g to 1000 nmoles/g fresh weight within 24 h. In addition, at the end of the assay, after 7 days, a 6-PG-concentration of about 150 nmoles/g fresh weight was still seen. Moreove, the G-6-P level simultaneously rose with the 6-PG-level to about 150% of the control level and returned to normal on the 5th day [2].

Clinical trial: So far, no clinical study has been conducted.

References:
[1] Street, J. C.,Alfieri, A.A. and Koutcher, J.A. Quantitation of metabolic and radiobiological effects of 6-aminonicotinamide in RIF-1 tumor cells in vitro. Cancer Research 57, 3956-3962 (1997).
[2] Lange, K.  and Proft, E.R. Inhibition of the 6-phosphogluconate dehydrogenase in the rat kidney by 6-aminonicotinamide. Naunyn-Schmiedeberg's Archives of Pharmacology 267, 177-180 (1970).

文献引用

化学属性

StorageStore at -20°C
M.Wt137.1
Cas No.329-89-5
FormulaC6H7N3O
Synonyms6-AN,NSC 21206,SR 4388
Solubilityinsoluble in H2O; insoluble in EtOH; ≥13.7 mg/mL in DMSO
Chemical Name6-amino-3-pyridinecarboxamide
SDFDownload SDF
Canonical SMILESNc1ccc(cn1)C(=O)N
运输条件 蓝冰运输或根据您的需求运输。
一般建议不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。

质量控制