切换导航
关闭
  • 菜单
  • Setting

5-Methyl-CTP

 
Catalog No.
B7967
A CTP analogue used for in vitro mRNA synthesis
组合的产品项目
规格价格库存 数量
10ul (100 mM)
¥ 463.00
现货
50ul (100 mM)
¥ 2,136.00
现货
100ul (100 mM)
¥ 3,654.00
现货

电话: 021-55669583

邮箱: sales@apexbio.cn

全球经销商

A

背景

5-Methyl-CTP is a modified nucleoside triphosphate, commonly used to substitute the naturally occurring cytidine triphosphate (CTP) during in vitro mRNA synthesis. Methylation of the cytosine C-5 position is a common, post-transcriptional modification for mRNA. Incorporation of chemically modified 5-methyl-CTP can increase mRNA stability and protein expression, and meanwhile, reduce interaction of innate immune receptors with in vitro-transcribed (IVT) mRNA. Apart from its application in encoding antigens for the activation of immune response against a variety of diseases such as COVID-19, IVT mRNA can also express the nanobody/variable domain of heavy chain of heavy-chain antibody targeting the intracellular components, enabling intracellular antigen labeling and manipulation.

References:

1. Rahman MM, Zhou N, Huang J. An overview on the development of mRNA-based vaccines and their formulation strategies for improved antigen expression in vivo. Vaccines (Basel), 2021, 9(3): 244.

2. Lu J, Lu G, Tan S, et al. A COVID-19 mRNA vaccine encoding SARS-CoV-2 virus-like particles induces a strong antiviral-like immune response in mice. Cell Research, 2020, 30(10): 936-939.

3. Zhou X, Hao R, Chen C, et al. Rapid delivery of nanobodies/VHHs into living cells via expressing in vitro-transcribed mRNA. Molecular Therapy - Methods & Clinical Development, 2020, 17: 401-408.

文献引用

化学属性

Physical AppearanceSolution
StorageStore at -20°C or below
M.Wt497.1 (free acid)
FormulaC10H18N3O14P3 (free acid)
Synonyms5-Methylcytidine-5'-Triphosphate, 5-Me-CTP, 5mCTP, 5-mCTP
SDFDownload SDF
Canonical SMILES[NH2]=C(C(C)=CN1C2C(O)C(O)C(COP([O-])(OP([O-])(OP([O-])([O-])=O)=O)=O)O2)=NC1=O.[Li+].[Li+].[Li+].[Li+]
运输条件 蓝冰运输或根据您的需求运输。
一般建议不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。

质量控制

质量控制和MSDS

批次:

化学结构

5-Methyl-CTP

相关生物数据

5-Methyl-CTP