5-hydroxypyrazine-2-carboxylic acid
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 140.1 |
| Cas No. | 34604-60-9 |
| Formula | C5H4N2O3 |
| Solubility | insoluble in EtOH; ≥7 mg/mL in DMSO; ≥7.63 mg/mL in H2O |
| Chemical Name | 5-hydroxypyrazine-2-carboxylic acid |
| SDF | Download SDF |
| Canonical SMILES | OC1=NC=C(C(O)=O)N=C1 |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
| 动物实验 [1]： | |
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动物模型 |
Sprague-Dawley雌性大鼠 |
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剂量 |
50mg/kg，100mg/kg（p.o.） |
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应用 |
通过反相高效液相色谱法在24小时尿液样品中对PZA及其三种主要代谢产物进行定量分析。咖啡因（100mg/kg）和PZA（50mg/kg）同时给药会增加水溶性最高和毒性最小的PZA代谢物5-hydroxypyrazine-2-carboxylic acid的排泄性（从66.18 +/- 10.87到94.56 +/- 8.65μM/24 h）。当施用100 mg /kg的PZA时，这种作用更加明显：将5-OH-PA的排泄从113.28 +/- 70增加到173.23 +/- 17.82 μM / 24 h。 这些结果表明，咖啡因的摄入会影响PZA的代谢。 |
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注意事项 |
请测试所有化合物在室内的溶解度，实际溶解度和理论值可能略有不同，这是由实验系统的误差引起的，属于正常现象。 |
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References: [1]. Mehmedagic A, Verite P, Menager S, Tharasse C, Chabenat C, Andre D, Lafont O. Investigation of the effects of concomitant caffeine administration on the metabolic disposition of pyrazinamide in rats. Biopharm Drug Dispos. 2002 Jul;23(5):191-5. doi: 10.1002/bdd.305. PMID: 12116050. |
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质量控制和MSDS
- 批次:
化学结构
