4SC-202
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
4SC-202是高效选择性和可口服的组蛋白去乙酰化酶(HDAC)抑制剂,尤其是I类HDAC同工酶,IC50值约为1 μM [1].
4SC-202能够选择性抑制重组I类HDAC同工酶,对HDAC-1\HDAC-2和HDAC-3的IC50值分别为1.2 μM\1.12 μM和0.57 μM.在Hela和RKO细胞的体外实验中,4SC-202能够以剂量依赖的方式诱导组蛋白H3的超乙酰化,EC50值为1.1 μM.此外,4SC-202能够诱导G2/M细胞周期停滞,增加亚G1细胞数量.换句话说,4SC-202能够诱导NSCLS细胞凋亡.4SC-202能够抑制人癌细胞系增殖,平均IC50值为0.7 μM.
体内试验:在A549NSCLC 异种移植模型和RKO结肠癌模型中,相比于其它抑制剂,4SC-202具有良好的耐受性,并以剂量依赖的方式抗肿瘤[1].
参考文献：
[1] Henning S W, Doblhofer R, Kohlhof H, et al. 178 Preclinical characterization of 4SC-202, a novel isotype specific HDAC inhibitor[J]. European Journal of Cancer Supplements, 2010, 8(7): 61.
| Storage | Store at -20°C |
| M.Wt | 619.71 |
| Cas No. | 1186222-89-8 |
| Formula | C30H29N5O6S2 |
| Solubility | insoluble in H2O; ≥2.4 mg/mL in EtOH with gentle warming and ultrasonic; ≥62 mg/mL in DMSO |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
质量控制和MSDS
- 批次:
化学结构
