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2-Imino-4-methylpiperidine (acetate)

 
Catalog No.
C5658
有效的NOS抑制剂
组合的产品项目
规格价格库存 数量
10mg
¥ 1,300.00
Ship with 10-15 days
25mg
¥ 2,816.00
Ship with 10-15 days
50mg
¥ 3,466.00
Ship with 10-15 days

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A

背景

2-Imino-4-methylpiperidine (acetate) is a potent NOS inhibitor [1]

Nitric oxide (NO) is an endogenously produced inorganic free radical gas which has been implicated in endothelium-dependent vascular relaxation, cell-to-cell communication, and cytotoxicity associated with phagocytic cells. NO is synthesized by three isoforms of nitric oxide synthase (NOS): nNOS, eNOS and iNOS [1].

2-Imino-4-methylpiperidine (acetate) is a 2-iminopiperidine class of NOS inhibitor. In the presence of a final L-arginine concentration of 30 μM, 2-Imino-4-methylpiperidine inhibited human iNOS, eNOS, and nNOS with IC50 values of 0.1, 1.1, and 0.2 μM, respectively. 2-Imino-4-methylpiperidine exhibited 9-fold and 1-fold selectivity for iNOS compared to eNOS and nNOS, respectively [1].

In LPS-treated rats, 2-Imino-4-methylpiperidine (10 mg/kg, po) inhibited plasma nitrite levels by 87%.

Reference:
[1].  Webber RK, Metz S, Moore WM, et al. Substituted 2-iminopiperidines as inhibitors of human nitric oxide synthase isoforms. J Med Chem. 1998 Jan 1;41(1):96-101.

化学属性

Physical AppearanceA crystalline solid
StorageStore at -20°C
M.Wt171.2
Cas No.165383-72-2
FormulaC6H12N2 · C2H3O2
Solubility≤5mg/ml in ethanol;5mg/ml in DMSO;5mg/ml in dimethyl formamide
Chemical Name3,4,5,6-tetrahydro-4-methyl-2-pyridinamine, acetate
SDFDownload SDF
Canonical SMILESCC1CCN=C(N)C1.CC([O-])=O
运输条件 蓝冰运输或根据您的需求运输。
一般建议不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。

质量控制

质量控制和MSDS

批次:

化学结构

2-Imino-4-methylpiperidine (acetate)