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2,4-DPDHIF-PH竞争性抑制剂,细胞通透性

2,4-DPD

产品编号:C4887
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规格 单价 库存 订购数量
50mg (solution) ¥819.00 10-15 工作日发货
100mg (solution) ¥1,456.00 10-15 工作日发货

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Sample solution is provided at 25 µL, 10mM.

质量控制

质量控制和MSDS

批次:

化学结构

2,4-DPD

2,4-DPD Dilution Calculator

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2,4-DPD Molarity Calculator

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化学性质

CAS号 41438-38-4 SDF Download SDF
别名 2,4-Diethylpyridine dicarboxylate
化学名 2,4-pyridinedicarboxylic acid, diethyl ester
SMILES O=C(OCC)C1=NC=CC(C(OCC)=O)=C1
分子式 C11H13NO4 分子量 223.2
溶解度 ≤50mg/ml in ethanol;20mg/ml in DMSO;30mg/ml in dimethyl formamide 储存条件 Store at -20°C
物理性状 A solution in ethanol 运输条件 试用装:蓝冰运输。
其他可选规格:常温运输或根据您的要求用蓝冰运输。
一般建议 为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。

产品描述

2,4-DPD is a cell permeable, competitive inhibitor of the oxygen-sensing enzyme HIF-α prolyl hydroxylase (HIF-PH) [1].

Hypoxia-inducible factor (HIF) is a transcription factor with a key role in cellular responses to hypoxia in a variety of organisms. The HIF system plays an important role in angiogenesis, erythropoiesis, energy utilization, glucose/energy metabolism, tumour development, and ischaemic/hypoxic disease. Genetic or pharmacological inactivation of the HIF hydroxylases results in a constitutive activation of the HIF pathway with little or even absent regulation by oxygen remaining. The oxygen-sensing enzyme HIF-α prolyl hydroxylase catalyzes hydroxylation of specific prolyl and asparaginyl residues in the regulatory HIF-α subunits [2].

Exposure to 2,4-DPD limited prolyl 4-hydroxylase activity in C. elegans., where their esters are hydrolyzed to form competitors of a -ketoglutarate. 2,4-DPD showed dramatic effects among the progeny. When exposed to a high level of 2,4-DPD (2.7 mM), all progeny died regardless of genotype of C. elegans. The dead embryos arrested at the twofold stage [1].

References:
[1] Friedman L, Higgin J J, Moulder G, et al.  Prolyl 4-hydroxylase is required for viability and morphogenesis in Caenorhabditis elegans[J]. Proceedings of the National Academy of Sciences, 2000, 97(9): 4736-4741.
[2] Schofield C J, Ratcliffe P J.  Signalling hypoxia by HIF hydroxylases[J]. Biochemical and biophysical research communications, 2005, 338(1): 617-626.