17-Hydroxyprogesterone
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
17-Hydroxyprogesterone是一种内源性孕激素和其他类固醇激素生物合成中的化学中间体，也是多种孕激素衍生物的母体化合物。
体外：研究发现17-Hydroxyprogesterone是一种孕酮受体（PR）激动剂，类似于孕酮。此外，17-Hydroxyprogesterone也是一种盐皮质激素受体（MR）的拮抗剂以及糖皮质激素受体（GR）的部分激动剂，具有非常低的效力，同样类似于孕酮[1]。
体内：先前大鼠体内研究发现表明，用即使适量的17-Hydroxyprogesterone降低血压可以是阻断炎症和子宫动脉血管收缩而提高窝产仔数的一种可行治疗选择[2]。
临床试验：临床上，已在新生儿筛查程序中将17-Hydroxyprogesterone作为生物标志物进行评估，以检测罕见但可能致命的遗传疾病，如先天性肾上腺增生。结果表明，呼吸窘迫综合征与较高的17-Hydroxyprogesterone水平有关。此外，研究发现较高的17-Hydroxyprogesterone和假阳性与较低的胎龄和出生体重显著相关，这与先前的报告一致[3]。
参考文献：
[1] Barbara J. Attardi, et al. Comparison of progesterone and glucocorticoid receptor binding and stimulation of gene expression by progesterone, 17-alpha hydroxyprogesterone caproate (17-OHPC), and related progestins. Am J Obstet Gynecol. 2007 Dec; 197(6): 599.e1–599.e7.
[2] Lorena M. Amaral, et al. 17- hydroxyprogesterone caproate significantly improves clinical characteristics of preeclampsia in the Rupp rat model. Hypertension. 2015 Jan; 65(1): 225–231.
[3] Ryckman KK,Cook DE,Berberich SL,Shchelochkov OA,Berends SK,Busch T,Dagle JM,Murray JC. Replication of clinical associations with 17-hydroxyprogesterone in preterm newborns. J Pediatr Endocrinol Metab.2012;25(3-4):301-5.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 330.46 |
| Cas No. | 68-96-2 |
| Formula | C21H30O3 |
| Solubility | insoluble in H2O; ≥16 mg/mL in EtOH with gentle warming; ≥31.6 mg/mL in DMSO |
| Chemical Name | (8R,9S,10R,13S,14S,17R)-17-acetyl-17-hydroxy-10,13-dimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3(2H)-one |
| SDF | Download SDF |
| Canonical SMILES | CC([C@@]1(O)CC[C@@]2([H])[C@]([C@]3([H])CC[C@@]21C)([H])CCC4=CC(CC[C@@]43C)=O)=O |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
质量控制和MSDS
- 批次:
化学结构
相关生物数据
