10-DAB (10-Deacetylbaccatin)
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
10-DAB（也称为10-脱乙酰基）是用于制备taxol的中间产物，taxol是从太平洋紫杉树短叶红豆杉（Taxus brevifolia）以及其他种属的红豆杉（Taxus）的树皮中分离出的抗白血病和肿瘤抑制剂。由于天然来源的taxol的可用率较低，10-DAB可以作为制备taxol及其衍生物的原材料。10-DAB可以很容易地从红豆杉叶中提取得到，它具有折叠的化学结构，C-13位的α羟基很容易与4α乙酰基作用形成氢键。
参考文献：
F. Gueritte-Voegelein, V. Senilh, B. David, D. Guenard and P. Potier. Chemical studies of 10-deacetyl baccatin III hemisynthesis of taxol derivatives. Tetrahedron 1986; 42(16): 4451-4460
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 544.59 |
| Cas No. | 32981-86-5 |
| Formula | C29H36O10 |
| Synonyms | 10-Deacetylbaccatin, 10-Deacetylbaccatine III, 10-DEACETYLBACCATIN-III |
| Solubility | ≥22.25 mg/mL in DMSO; insoluble in H2O; ≥3.96 mg/mL in EtOH with ultrasonic |
| Chemical Name | (2aR,4R,4aS,6S,9S,11S,12S,12aR,12bS)-12b-acetoxy-4,6,9,11-tetrahydroxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxet-12-yl benzoate |
| SDF | Download SDF |
| Canonical SMILES | O[C@](C(C)(C)C1=C(C)[C@H]2O)(C2)[C@H]([C@@H]([C@@](C([C@H]1O)=O)(C)[C@@H]3O)[C@]4([C@@H](C3)OC4)OC(C)=O)OC(C5=CC=CC=C5)=O |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
| 描述 | 10-DAB（10-脱乙酰基）是一种抗肿瘤剂和抗肿瘤中间产物。 | |||||
| 靶点 | Cytoskeleton | |||||
| IC50 | ||||||
质量控制和MSDS
- 批次:
化学结构
